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Molecular mechanisms of bacterial proteins involved in host recognition and defense

Pathogenic bacteria employ a large repertoire of molecular weapons known as virulence factors to infect the host and cause disease. In particular, autotransporter proteins, the largest family of secreted virulence factors in Gram-negative bacteria, promote bacterial colonisation, biofilm formation and host cell invasion and/or damage (1). In response, host cells deploy various antimicrobial strategies, such as the mobilisation of copper at the site of infection, which induces bacterial stress.Despite the abundance of autotransporters and their roles in infection, their mechanisms …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Molecular modelling of GAG-protein interactions

Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are negatively-charged polysaccharide compounds. They are a key constituent of the extracellular matrix and act as a filler substance between cells and fibres in tissues. These molecules also play a role in several viral infections, in which they enhance cell entry and release of the viruses.Interest continues to grow in understanding the precise nature of the interactions between GAGs and their binding partners and in defining specific biologically active sequences or arrangements of domains.Existing …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Genomics and Personalised Health

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