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Interaction between pollen proteases and ACE2 receptor of SARS-CoV-2

Pollen allergy is a common seasonal respiratory disease triggered by hypersensitivity to pollen affecting 10-30% of adults and 40% of children, and is a predisposing factor for asthma. Pollens interact with airway epithelium to both stimulate innate immunity and elicit an adaptive immune response.Proteolytic activity is one route that stimulates release of alarmins and pro-inflammatory cytokines from mucosal epithelia. Previous studies have found the expression of Serine/Cysteine (Ser/Cys) proteases in some types of grass pollen grains, but it is not …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Allergen transcriptome of Bahia grass pollen and interaction with SARS-CoV2

Pollen allergy is a common seasonal respiratory disease triggered by hypersensitivity to pollen affecting 10-30% of adults and 40% of children, and is a predisposing factor for asthma. The sources of grass pollens differ between climate zones with subtropical grass pollens such as Bahia grass (Paspalum notatum), Johnson grass (Sorghum halepense) and Bermuda grass (Cynodon dactylon) being abundant in Queensland.Pollens interact with airway epithelium to stimulate both adaptive and innate immunity. Proteolytic activity is one route that stimulates release of …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

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