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Found 6 matching student topics

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The role of vaginal co-infections in pregnancy and neonatal outcomes

Group B Streptococcusi (GBS; Streptococcus agalactiae) is a leading pathogen that is responsible for neonatal meningitis and sepsis. Up to 40% of pregnant women have asymptomatic vaginal colonisation, and this can lead to chorioamnionitis, premature rupture of membranes and urinary tract infections, while vertical transmission from mother to baby can cause pneumonia, meningitis, sepsis and death of the neonate.There is increasing evidence that reproductive tract coinfections withGBS are occurring (eg. HSV, Candida albicans, Mycoplasma spp.), and maycontribute to poor pregnancy …

Study level
PhD, Master of Philosophy
Faculty
1043076
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

Characterisation of a novel protein co-amplified with the n-MYC oncogene

The MYCN oncogene is amplified in a number of tumour types, including Neuroblastoma (NB) and Neuroendocrine Prostate Cancer (NEPC), where it is associated with worse patient prognosis, as compared to non-amplified tumours. However, the high expression of MYCN (encoding the n-MYC protein) alone in non-amplified tumours is associated with better patient prognosis and less aggressive disease. This suggests that other genes co-expressed in MYCN amplified tumours may be responsible for mediating the aggressive traits of n-MYC. Our team has identified …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

A novel molecular targeted therapy for anaplastic prostate cancer

In advanced PCa, where the cancer has spread into the bone and other organs, the emergence of treatment resistance remains inevitable. For decades the primary form of treatment in advanced PCa has been to target the production and actions of male sex hormones, androgens, the primary developmental and survival factor of prostate tissue. While these therapies result in tumour regression and cancer control, this is temporary and treatment resistance occurs, referred to as castrate resistant prostate cancer (CRPC). In the …

Study level
Master of Philosophy, Honours
Faculty
1043076
School
School of Biomedical Sciences

Finetuning biofilm properties through the adjustment of cell surface polysaccharide and adhesin productions (CIIC01)

Biofilm is a lifestyle in which microbial cells form a community enclosed in an extracellular matrix. Much of the physicochemical properties of biofilms are dictated by the binding of adhesin molecules to living or environmental surfaces, as well as the production of polysaccharides within the matrix.Escherichia coli produce a wide repertoire of polysaccharides and adhesins and their role in determining biofilm properties will be investigated in this project.The student will learn genetic engineering of bacterial strains using state-of-art molecular techniques …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

Post-translational modification of proteins in cancer

The Protein Ablation Cancer Therapeutics (PACT) laboratory are interested in understanding how post-translational modifications contribute to the tumorigenic functions of proteins in cancer cells. We hypothesise that particular post-translational modifications are required for the cancer-associated function of a protein and that prevention of these would be a useful approach to treating cancer.The aim of this project is to select a candidate protein from our database of potential targets, confirm the protein is modified, identify the key modified lysine in the …

Study level
PhD, Master of Philosophy, Honours
Faculty
1043076
School
School of Biomedical Sciences

Illuminating the microbial world using genome-based fluorescence microscopy

Our understanding of microbial diversity on earth has been fundamentally changed by metagenomic characterisation of natural ecosystems. Traditional approaches for visualising microbial communities are time-consuming and provide limited information about the identity of specific microorganisms.The proposed research aims to combine single cell genomics and super resolution microscopy for novel, high-throughput, genome-based techniques to visualise microorganisms, plasmids and viruses, with strain level specificity.The application of these highly scalable approaches will provide comprehensive and unprecedented insight into the fine-scale dynamics and evolution …

Study level
PhD
Faculty
1043076
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

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