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Understanding the role of TGF signalling intermediates in liver and iron-related disease

Transforming growth factor β (TGFβ) and its family members is involved in many phases of liver disease development and iron regulation. We have identified unexplored players in liver disease and iron-related disorders: TGF signalling intermediates. In this project, we build on our exciting findings to examine the molecular mechanisms involved in TGF signalling intermediates-mediated disease progression and their potential as targets for liver and iron-related disease.AimsThis project aims to:examine the expression of TGF signalling intermediates in the liverspecifically deplete TGF …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Developing models of failure for porous materials

The field of fracture mechanics effectively models failure of sharp flaws (e.g., cracks). However, when modelling porous materials we'd like to develop more of an understanding of how stresses are concentrated around smooth flaws in the material (i.e., rounded pores).In this project we'll start to build such an understanding, starting from simple U shaped notches.

Study level
Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Mathematical Sciences

Cyber-security aspects of battery storage systems

Lithium-ion (Li-ion) batteries are a key energy storage component in various electrical and electronic systems such as mobile phones, electric vehicles and grid storage. A properly designed battery management system (BMS) is crucial to guarantee the safety, reliability, and optimal performance of the battery as well as to interconnect the battery systems with each other and external systems through communication channels. However, security threats of the Li-ion battery systems are often overlooked by BMS developers in the design phase. The …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Engineering
School
School of Electrical Engineering and Robotics
Research centre(s)

Centre for Clean Energy Technologies and Practices

Decision modelling in blockchain adoption and environmental implications

Due to the decentralised and immutable nature of distributed ledger systems, blockchain has become a critical priority for organisations across the world. The global blockchain market is expected to grow from $1.57 billion in 2018 to $162.84 billion by 2027.From an ecological perspective, blockchain has raised environmental concerns due to increasing computational power that is required to operate energy-intensive consensus mechanisms. However, it also has the potential to help promote renewable energy through a variety of blockchain-based use cases such …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Information Systems

Decision modelling to overcome intergenerational discounting

This project aims to address a key obstacle to climate action: intergenerational discounting, a phenomenon that explains the tendency for people to prefer smaller benefits for themselves now, rather than larger benefits for future generations. Intergenerational discounting becomes even more problematic due to a growing global population and increasingly intensive use of natural resources.In this project, we follow the design science approach and aim to establish design principles necessary for decision modelling to overcome intergenerational discounting and achieve genuine and …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Information Systems

Business model pivoting: How women entrepreneurs leverage opportunities generated by the COVID-19 pandemic

The Covid-19 pandemic is unique in the severity of its impact disrupting global supply chains, international trade and investment, health, and education. The impacts of crises are never gender-neutral, and Covid-19 is no exception. Research indicates that the pandemic has disproportionately affected women entrepreneurs who face unprecedented challenges as their firms tend to be younger and smaller. Despite the unparalleled challenges discussed, Covid-19 is likely to offer important opportunities for discerning international entrepreneurs (Zahra, 2021).This research seeks to understand how …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Business and Law
School
School of Advertising, Marketing and Public Relations
Research centre(s)

Australian Centre for Entrepreneurship Research

An airway chip for screening viral infection mediated immune responses

Respiratory infections such as influenza, SARS-COV-2, , and MERS are increasingly prevalent. Complications and related deaths arising from these infections are often the result of a “cytokine storm”, whereby there is an over production of proinflammatory soluble factors by immune cells, which dictates symptoms severity and mortality risk [1]. Recent works showed that immunomodulatory therapy with or without antiviral agents may improve recovery outcome. However, the screening of suitable immune-modulatory and antiviral agents relies heavily on animal models which cannot …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Molecular modelling of GAG-protein interactions

Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are negatively-charged polysaccharide compounds. They are a key constituent of the extracellular matrix and act as a filler substance between cells and fibres in tissues. These molecules also play a role in several viral infections, in which they enhance cell entry and release of the viruses.Interest continues to grow in understanding the precise nature of the interactions between GAGs and their binding partners and in defining specific biologically active sequences or arrangements of domains.Existing …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Genomics and Personalised Health

Molecular modelling and simulations of anionic molecules

Biomolecular recognition refers to the interaction between a macromolecule (usually a protein or a nucleic acid) and a target molecule. Most often obtaining 3D experimental data is not trivial at atomistic scale. Computational methods offer the possibility of precisely describing all types of ligand–macromolecule interactions and are therefore a promising avenue to obtain that information, to test or discard a large variety of hypotheses regarding molecular recognition, folding of proteins/peptides and/or to select, among the vast chemical space of potential …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Genomics and Personalised Health

Targeting a novel adaptive neovascular response of the tumour microenvironment to treat advanced prostate cancer

Prostate cancer (PCa) is a significant healthcare burden in Australia. Androgen signalling inhibition using androgen receptor (AR) antagonists is the principal systemic therapy for advanced PCa. Androgen receptors (AR) are an attractive therapeutic target due to their elevated expression in tumour epithelial cells and the retention of androgen signalling throughout the disease continuum.However, patients eventually develop resistance to treatment, and PCa cells metastasise to distant bone and visceral organs, representing an incurable stage of the disease. Understanding mechanisms that contribute …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Development of methods to analyse cells in 3D bioengineered human tumour models

Over the past few decades, cancer mortality has risen more than 2.6-folds in Australia, mandating novel research to study and understand the mechanisms of cancer biology. Recent advancements in technology have led to development of novel scaffold-based, bioengineered 3D tumour models that recapitulate the complex, in vivo cancer microenvironment better than the conventional 2D monolayer cultures.Specifically, tumour cells encapsulated in hydrogel systems are widely used as effective 3D tumour models because of how closely they mimic the native tissue extracellular …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Development of 3D tumour models for radiobiological research

Approximately 40 percent of cancer patients will receive radiation therapy as part of the management of their disease. Radiation can be used alone or in combination with other treatment modalities such as surgery, chemotherapy, and increasingly immunotherapy.Optimising the delivery of radiation, to take advantage of new treatment planning and delivery techniques, or to test new combinations of treatment modalities in a pre-clinical setting, has traditionally been performed using single layer 2D cell cultures and small animal models.Recently, it has become …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

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