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Using mathematics to understand multiple sclerosis: what causes the immune system to attack the brain?

Every day, we use our bodies to move, think, talk and eat, but for people with multiple sclerosis (MS) these tasks can be virtually impossible. MS is a chronic disease which develops because the immune system has started to attack the nerve cells in the brain. This causes the degradation of parts of the brain and irreversible impairment in physical and mental activity. Unfortunately, this disease has no cure, and while considerable therapeutic advances against this disease have been achieved, …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Mathematical Sciences

Increased heat transfer and reduced scaling of evaporator tubes

Multi effect evaporators are a key component of industrial processing. In the sugar cane industry they provide high energy efficiency and good control resulting in good quality product. However the evaporation of water from the sugar juice results in scaling of the internal surface of the tubes, with decreasing heat transfer over a few weeks reducing throughput. A 10 hour stop is then required to clean the evaporators with chemicals. A method of increasing heat transfer and reducing the scaling …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Agriculture and the Bioeconomy

Monte-Carlo modelling in radiotherapy

Various research projects are available in the use of monte-carlo techniques in radiotherapy and medical imaging. These include modelling radiotherapy linear accelerators, radiobiology, patient dosimetric verification and in-vivo treatment verification using electronic portal imaging devices.span

Study level
Vacation research experience scheme
Faculty
Faculty of Science
School
School of Chemistry and Physics
Research centre(s)
Centre for Biomedical Technologies

Modelling of 3D printable flexible sensor designs for healthcare applications

Each year, millions of people suffer from traumatic tissue damage due to cancers, congenital defects or injury. Biofabrication is the rapid 3D printing of replacement tissue and organs that are customised to the specific needs of the patient. This future of manufacturing technology is set to revolutionise regenerative medicine and deliver high quality health outcomes. The Biofabrication and Tissue Morphology group is a world class multi-disciplinary research team focused on embedding biofabrication into routine clinical use.Based at our state-of-the-art labs …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Modelling the response of expansive soil under wetting and drying

Expansive soils are those which can experience significant volume change when water content varies and as of this reason they are considered as problematic soils in geotechnical engineering. Expansive soils are widely distributed globally and cover a significant percentage of world land surface, especially in arid and semi-arid area.In Australia, expansive soil covers around 20% of surface soils and approximately 30% of the total ‘built-up’ land area is covered by expansive soils. This figure is expected to increase, as the …

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Civil and Environmental Engineering
Research centre(s)
Centre for Materials Science

Modeling Australian rainfall extremes using extreme value methods

To mitigate the risk posed by extreme rainfall events, we require statistical models that allow us to extrapolate outside the range of our observed data into the tail of our distribution and to estimate the probability of record events we are yet to observe.For this type of statistical analysis, we typically use methods from extreme value theory. The challenge for modelling rainfall extremes using many of these extreme value methods is that there exists a gap between theory and practice. …

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Mathematical Sciences
Research centre(s)
Centre for Data Science

Modelling convection in porous media

When liquids of different densities mix, they can produce complex fingering patterns. This is particularly important in the flow of liquid in underground porous aquifers, where the density of the groundwater can be influenced by salinity or heat, as well as the insulation properties of porous materials. Another important application is the still-prototypical use of aquifers for carbon sequestration; the dissolution of CO2 into groundwater has a complex effect on its density, and convective mixing is crucial for accelerating the …

Study level
Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Mathematical Sciences

Modelling interactions between viral surface and polymeric anti-viral drugs

In 2020, the impact of emerging viral infections on human health and socioeconomic development has been made glaringly apparent by the COVID-19 pandemic, caused by SARS-CoV-2. While SARS-CoV-2 is having a global impact, other viral infections are major contributors to morbidity and mortality around the world. Therefore, we need to have broad spectrum therapeutics on hand that can reduce disease severity, regardless of which viral strain causes the next pandemic.This project aims to develop broad spectrum antiviral polymeric nanoparticles, to …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering

Modeling roost selection by flying foxes in Moreton Baty region

Study level
Honours
Faculty
Faculty of Business and Law
School
School of Accountancy

Understanding the immunological mechanisms that regulate increased susceptibility to respiratory syncytial viral infection after stem cell transplantation

Allogeneic stem cell transplantation (alloSCT) is considered the gold standard procedure for the treatment of blood cancers. Globally, over 9000 patients per year undergo this high-risk, life-saving therapy. However, major complications limit the therapeutic potential of this treatment which include graft-versus-host disease (GVHD) and infections due to the severe immunosuppression in these patients. Respiratory syncytial viral (RSV) infection is frequent in these patients, is often fatal and clearly a significant clinical problem. Thus, there is a pressing need for new …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Development of bioengineered 3D tumour models for preclinical breast cancer research

3D organoid model technologies have led to the development of innovative tools for precision medicine in cancer treatment. Yet, the lack of resemblance to native tumours, and the limited ability to test drugs in a high-throughput mode, has limited translation to practice.This project will progress organoid models by using advanced tissue engineering technologies and high-throughput 3D bioprinting to recreate 'mini-tumours-in-a-dish' from a patient’s own tumour cells, and study the effects of various components of the tumour microenvironment on drug response.In …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Biomedical Technologies

Developing in vitro 3D models to understand liver disease

Several studies have demonstrated the appropriateness of 3D organoid cultures over the conventional 2D cultures, the advantages of 3D models include replicating the complex attributes of the liver beyond liver-specific metabolism, such as increased cell density, organization, and cell–cell signalling, O2 zonation.In this project we will establish a novel in vitro 3D model to study hepatocyte biology in the context of liver disease. A more comprehensive approach to investigating the intercellular mechanisms of NAFLD will include co-culture of organoids with …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

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