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Protein biomarkers to predict immunotherapy response in lung cancers

Immunotherapy has revolutionised cancer treatment in the recent years. It has been successfully used to treat several melanoma and lung cancer patients. However, not all patients respond to immunotherapy. There is a clinical need for biomarkers that can identify lung cancer patients that are most likely to benefit from immunotherapy.In this project, we will employ mass spectrometry-based proteomics approaches to carry out proteomic profiling of mononuclear cells and plasma samples from lung cancer patients treated with immunotherapy. Proteome profiles of …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences

Improving platinum-based chemotherapy by targeting drug metabolism in lung cancer

Lung cancer is the deadliest cancer accounting for 18.4% of all cancer-related deaths. Platinum-based chemotherapy remains a key treatment option for most people living with this disease, either as adjuvant therapy or in combination with immunotherapy. However, resistance to therapy is a significant issue in the treatment of lung cancer. Novel therapeutic strategies combined with predictive biomarkers chemotherapy response are needed to transform the clinical management of NSCLC.Our published work has identified novel biomarkers and druggable proteins from deregulated protein …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

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