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Male chlamydia infections: the key role of macrophages in testicular dissemination and disrupted spermatogenesis

Chlamydia trachomatis is an obligate intracellular, bacterial pathogen. Chlamydia infections of the human reproductive tract affect approximately 131 million people globally each year. The major concern of chlamydial infections is its ability to cause infertility in both men and women, by damaging the upper reproductive tracts.The testis is a tightly regulated, immune-privileged, environment. The key cell types (Macrophages, Leydig, Sertoli and Germ cells) each play a specific role in regulating spermatogenesis (production of sperm).Our lab has found that chlamydial infections …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

Improving cow fertility: targeting exosome-responsive pathways

Exosomes are small (40-120 nm), stable, lipid bilayer nanovesicles identified in biological fluids (e.g. in Until recently, genetic selection in dairy cows has focused primarily on milk production traits, with very few countries including functional traits such as fertility in selection indices. Poor reproductive efficiency in dairy herds results in fewer calves, reduced milk production, high involuntary culling rates and increased cow maintenance costs. The need for, and utility of, markers of early onset of diseases (or vulnerability to diseases) …

Study level
PhD, Master of Philosophy
Faculty
Faculty of Health
School
School of Biomedical Sciences

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