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Development of methods to analyse cells in 3D bioengineered human tumour models

Over the past few decades, cancer mortality has risen more than 2.6-folds in Australia, mandating novel research to study and understand the mechanisms of cancer biology. Recent advancements in technology have led to development of novel scaffold-based, bioengineered 3D tumour models that recapitulate the complex, in vivo cancer microenvironment better than the conventional 2D monolayer cultures.Specifically, tumour cells encapsulated in hydrogel systems are widely used as effective 3D tumour models because of how closely they mimic the native tissue extracellular …

Study level
Vacation research experience scheme
Faculty of Engineering
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Understanding the role of the hSSB1 protein in the response to UV induced DNA damage

Melanoma is the 4th most common cancer in Australia. The link between skin cancer and UV exposure is now well established. If a DNA damage induced by UV exposure is left unrepaired, the mutation generated in the genome can lead to cell death or cancer. It is thus highly important to understand of how a cell can repair DNA damage. The main pathway to repair UV DNA damaged is the nucleotide excision repair pathway (NER) (Kamileri I. et al, Trends …

Study level
Faculty of Health
School of Biomedical Sciences

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