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Investigating hepcidin regulation in hereditary haemochromatosis

Iron is an essential nutrient, but is also toxic when in excess, so the amount of iron in the body must be tightly controlled. As mammals don’t actively excrete iron, body iron levels are regulated at the point of absorption in the small intestine. This process is controlled by the hormone hepcidin which is secreted by the liver in response to iron requirements.Circulating hepcidin binds to the iron export protein ferroportin on intestinal cells, causing the protein complex to be …

Study level
Vacation research experience scheme
Faculty of Health
School of Biomedical Sciences

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