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Understanding the immunological mechanisms that regulate increased susceptibility to respiratory syncytial viral infection after stem cell transplantation

Allogeneic stem cell transplantation (alloSCT) is considered the gold standard procedure for the treatment of blood cancers. Globally, over 9000 patients per year undergo this high-risk, life-saving therapy. However, major complications limit the therapeutic potential of this treatment which include graft-versus-host disease (GVHD) and infections due to the severe immunosuppression in these patients. Respiratory syncytial viral (RSV) infection is frequent in these patients, is often fatal and clearly a significant clinical problem. Thus, there is a pressing need for new …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Spatial localisation of immunoglobulin A in the gastrointestinal tract.

Blood cancers, which include leukaemia, lymphoma and myeloma account for 10% of all cancers and 9.4% of cancer deaths. Stem cell transplantation (SCT) is the predominant curative therapy for these diseases. However, a major complication is graft-versus-host disease (GVHD) in which the gastrointestinal (GI) tract, skin, lung and liver are preferentially damaged by the transplanted donor immune system, limiting the therapeutic potential of this treatment. Thus, there is a pressing need for new treatment approaches to improve transplant outcome for …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Application of fluorescence-activated cell sorting and confocal microscopy for the study of the microbial communities responsible for nutrient removal from domestic wastewater

The removal of nutrients like carbon, nitrogen and phosphorus from wastewater is critical to the prevention of eutrophication in receiving water systems and is carried out by complex microbial communities.Eutrophication can have devastating consequences on aquatic life and natural ecosystems, with toxic algal blooms also posing a risk to human health.Understanding the microbiology of phosphorus (P) removal from wastewater is considered essential to knowledge-based optimisation of enhanced biological P removal (EBPR) systems.Most of the species in these systems are novel …

Study level
Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Microbiome Research

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