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Image-based computational model to predict intracranial aneurysm rupture

Intracranial aneurysms are bulging, weak areas of an artery that supply blood to the brain which are relatively common. While most aneurysms do not show symptoms, 1% spontaneously rupture which can be fatal or it can leave the survivor with permanent disabilities. This catastrophic outcome has motivated surgeons to operate on approximately 30% of aneurysms despite their rate of complications arising and cost of operation.The impact of aneurysm morphology on blood flow shear stress and rupture could educate surgical decision-making …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies
Centre for Biomedical Technologies

Image-based assessment of atherosclerotic plaque vulnerability: Towards a computational tool for early detection and prediction

Plaque characteristics and local haemodynamic/mechanical forces keep changing during plaque progression and rupture. Quantifying these changes and discovering the progression-stress correlation can improve our understanding of plaque progression/rupture. This will lead to a quantitative assessment tool for early detection of vulnerable plaques and prediction of possible ruptures. Our research project aims to combine medical imaging, computational modelling, phantom experiments and pathological analysis to investigate plaque progression and vulnerability to rupture in both animal models and patients with carotid stenosis. We …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies
Centre for Biomedical Technologies

Experimental and numerical microfluidics

Miniaturisation is one of the most important current drivers for chemical and biological processes involved in gas sensing, water purification, cell culture and separation, and micro-reactors, among others, as it contributes to reducing costs while increasing performance and efficiency. The manipulation of small amounts of fluids at the microscale (microfluidics) offers several advantages such as speed, precision and control of those physical processes and holds the potential to deliver transformative technology capable of achieving fast, accurate and economical industrial solutions.With …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering

Red blood cell modelling

Red blood cells (RBCs) require high deformability to sustain their passage through narrow capillaries of the microvasculature, which is primarily influenced by mechanical and geometrical factors of the cell. Ageing of the cell, several diseased conditions and some extracellular conditions adversely affect the cell morphology and deformability leading to cell rupture during micro-circulation and vesiculation (i.e. the process of removal of defective patches of the RBC membrane forming spherocytes that is associated with the loss of both RBC membrane and …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering

New mathematical and computational techniques for modelling with partial differential equations

Mathematical models involving partial differential equations (PDEs) are useful for simulating many important physical processes including heat and mass transfer, groundwater flow, pollutant transport and drug delivery. This project will focus on developing new mathematical and computational techniques to solve, approximate and/or analyse PDE models.Potential project topics include:developing new numerical and/or analytical methods for solving PDE modelsbuilding new reduced-order PDE models that are easier to solve, interpret or analyseextracting insight into time scales of PDE models, such as the amount …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Mathematical Sciences

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