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Image-based computational model to predict intracranial aneurysm rupture (VRES)

Intracranial aneurysms are bulging, weak areas of an artery that supply blood to the brain which are relatively common. While most aneurysms do not show symptoms, 1% spontaneously rupture which can be fatal or it can leave the survivor with permanent disabilities. This catastrophic outcome has motivated surgeons to operate on approximately 30% of aneurysms despite their rate of complications arising and cost of operation.The impact of aneurysm morphology on blood flow shear stress and rupture could educate surgical decision-making …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Image-based assessment of atherosclerotic plaque vulnerability: Towards a computational tool for early detection and prediction

Plaque characteristics and local haemodynamic/mechanical forces keep changing during plaque progression and rupture.Quantifying these changes and discovering the progression-stress correlation can improve our understanding of plaque progression/rupture. This will lead to a quantitative assessment tool for early detection of vulnerable plaques and prediction of possible ruptures.Our research project aims to combine medical imaging, computational modelling, phantom experiments and pathological analysis to investigate plaque progression and vulnerability to rupture in both animal models and patients with carotid stenosis.We will identify and …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Image-based computational model to predict intracranial aneurysm rupture

Intracranial aneurysms are bulging, weak areas of an artery that supply blood to the brain which are relatively common. While most aneurysms do not show symptoms, 1% spontaneously rupture which can be fatal or it can leave the survivor with permanent disabilities. This catastrophic outcome has motivated surgeons to operate on approximately 30% of aneurysms despite their rate of complications arising and cost of operation.The impact of aneurysm morphology on blood flow shear stress and rupture could educate surgical decision-making …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

Simulation of bacterial cell motion using CFD and DPM methods

Studying bacterial motion under flow conditions demands greater amount of resources. Computer simulations can reduce the need for expensive experimental investigations by predicting bacterial motion under specific flow conditions.Computer Fluid Dynamics (CFD) is used to analyse fluid flow using computer simulations, and Discrete Phase Method (DPM) is used to analyse flow of particles in a fluid. Combining these two methods, bacterial motion under fluid flow has been simulated.However, these simulation models have limitations such as absence of bacterial interactions, or …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering

Simulation of turbulent fluid flow through a microfluidic device using CFD

Microfluidic devices (MFD) are extensively used in microbial studies. Bacterial cell attachment onto surfaces under flow conditions in laminar regime has been previously studied using a custom designed MFD.As an extension of this study, microbial attachment under turbulent flow is to be studied in a future project. The suitability of current MFD for microbial studies under turbulent flow must be evaluated to adopt / redesign the MFD.A computational fluid dynamics (CFD) analysis is proposed to examine the fluid flow inside …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering

Increased heat transfer and reduced scaling of evaporator tubes through computational fluid dynamics modelling

Multi effect evaporators are a key component of industrial processing. In the sugar cane industry they provide high energy efficiency and good control resulting in good quality product.However the evaporation of water from the sugar juice results in scaling of the internal surface of the tubes, with decreasing heat transfer over a few weeks reducing throughput. A 10 hour stop is then required to clean the evaporators with chemicals.A method of increasing heat transfer and reducing the scaling rate would …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Agriculture and the Bioeconomy

Developing bacterial cell rupture model on a nanotextured surface using finite element computational fluid dynamics (CFD) technique.

Nanoscale roughness on the materials as that of the cicada and dragonfly wings exhibited strongly antimicrobial properties that repel and/or kill bacteria. The nano-texture is usually produced by applying wet-chemical etching, electrochemical etching, and hydrothermal processes. Nano-textured Al 5005 and Al 6063 were tested against gram-negative Escherichia coli (E coli) bacterial cell, and observed bactericidal. In order to understand the killing mechanism and the optimum geometry of the nanotexture, computational study is often time saving and more viable than the …

Study level
Vacation research experience scheme
Faculty
Faculty of Engineering
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

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