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Male chlamydia infections: the key role of macrophages in testicular dissemination and disrupted spermatogenesis

Chlamydia trachomatis is an obligate intracellular, bacterial pathogen. Chlamydia infections of the human reproductive tract affect approximately 131 million people globally each year. The major concern of chlamydial infections is its ability to cause infertility in both men and women, by damaging the upper reproductive tracts.The testis is a tightly regulated, immune-privileged, environment. The key cell types (Macrophages, Leydig, Sertoli and Germ cells) each play a specific role in regulating spermatogenesis (production of sperm).Our lab has found that chlamydial infections …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)

Centre for Immunology and Infection Control

Infection kinetic changes that occur within macrophage-adapted Chlamydia

Chlamydia trachomatis is an obligate intracellular, bacterial pathogen. C. trachomatis infections of the human reproductive tract affect approximately 127 million people globally each year. The major concern of C. trachomatis infections is their ability to cause infertility in both men and women, by damaging the upper reproductive tracts. However, we are still lacking information about how Chlamydia travels around the reproductive tract, and reaches the upper tract (ovaries and testes in particular) to cause this damage.Recent research has shown that …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

Testing of novel antibiotic-loaded nanoparticles for treatment of Chlamydia infection

C. trachomatis, sexually transmitted infections of both the female and male human reproductive tract, affects approximately 127 million people globally each year. The major concerning sequela of C. trachomatis infection is infertility in both men and women. This occurs by damaging the upper reproductive tracts, the ovaries and testes most importantly.The majority of research has been focussed on female disease, and male disease has been underestimated and understudied, particularly therapeutics for male infections. Antibiotic therapy is the only therapy currently …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences

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