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Development of bioengineered 3D tumour models for preclinical breast cancer research

3D organoid model technologies have led to the development of innovative tools for precision medicine in cancer treatment. Yet, the lack of resemblance to native tumours, and the limited ability to test drugs in a high-throughput mode, has limited translation to practice.This project will progress organoid models by using advanced tissue engineering technologies and high-throughput 3D bioprinting to recreate ‘mini-tumours-in-a-dish’ from a patient’s own tumour cells, and study the effects of various components of the tumour microenvironment on drug response.In …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Biomedical Technologies

Bio-inspired design to create strong and toughness composites

A fundamental challenge when designing materials for mechanical use is to attain both strength and toughness in one body. Conventional metallic materials generally have relatively large plasticity due to having a massive population of microstructural defects and effective plastic deformation mechanism. This has been exploited for fabricating tolerant (toughness) materials for structural applications. However, these structural defects render the materials relatively low strength and a low load-bearing capability. In contrast, ceramics and intermetallic compounds have higher strengths, owing to their …

Study level
PhD, Master of Philosophy, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

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