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Resurrecting ancient enzymes for high-temperature biocatalysis

Cytochrome P450 enzymes (P450s) can be used to perform a range of chemical transformations with exquisite selectivity that can be difficult or sometimes impossible to achieve with conventional synthetic chemistry. However, most enzymes are incompatible with the high temperatures encountered in industrial processes.Ancestral protein reconstruction is a computational technique where you can try to predict an ancient protein sequence by building a phylogenetic tree based on evolutionarily-related sequences from the present day. Professor Elizabeth Gillam from The University of Queensland …

Study level
Vacation research experience scheme
Faculty
Faculty of Science
School
School of Biology and Environmental Science
Research centre(s)
Centre for Agriculture and the Bioeconomy

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