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Targeting leptin's signalling axis to prevent treatment resistance in prostate cancer

Advanced prostate cancer (PCa) is a leading cause of cancer-associated death in Australian men. Anti-androgens, which exploit the tumour’s reliance on androgens for its growth & spread, offer temporary remission in advanced PCa patients, but due to treatment resistance, fail to be curative. A further complication of anti-androgens is that they trigger a deleterious suite of metabolic side-effects resembling obesity/Metabolic syndrome. These symptoms not only impact patient health but promote tumours to be more aggressive & resist treatment. Vital new …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

Restoring adiponectin signalling to prevent prostate cancer progression

Advanced prostate cancer (PCa) is a leading cause of cancer-associated death in Australian men. Anti-androgens, which exploit the tumour’s reliance on androgens for its growth & spread, offer temporary remission in advanced PCa patients, but due to treatment resistance, fail to be curative. A further complication of anti-androgens is that they trigger a deleterious suite of metabolic side-effects resembling obesity/Metabolic syndrome. These symptoms not only impact patient health but promote the tumour to be more aggressive & resist treatment. Vital …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

Automating drone traffic management systems

Unmanned Traffic Management (UTM) describes a set of systems, services and procedures that will be developed to manage drone (unmanned aircraft systems/unmanned aerial vehicle/remotely piloted aircraft system) operations in and around our cities, including package delivery and inspection tasks and passenger transport.Essentially, UTM is a new air traffic control system for drones with high levels of automation and advanced features. We are developing powerful and scalable technologies that allow thousands of drones to operate safely in our skies. …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Electrical Engineering and Robotics

Targeting Fibrosis: Identification of novel natural compounds to modulate collagen expression

Liver disease is a huge and increasing burden on society; it can be due to a number of different reasons including excessive alcohol consumption, viral infections, and non-alcoholic liver disease. Each of these causes may have a different molecular pathway of developing the disease pathology, but one common feature is there is an injury or insult to the liver. This injury then results in activation of the wound healing process; when this healing process goes awry liver disease can develop, …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

A biofabrication surgical referral suite to predict intracranial aneurysm rupture

Intracranial aneurysms are bulging, weak areas of an artery that supply blood to the brain which are relatively common. While most aneurysms do not show symptoms, 1% spontaneously rupture which can be fatal or leave the survivor with permanent disabilities. This catastrophic outcome has motivated surgeons to operate on approximately 30% of aneurysms despite their rate of complications arising and cost of operation.The impact of aneurysm morphology on blood flow shear stress and rupture could educate surgical decision-making and better …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

Mathematical modelling of the mechanobiology during plaque growth

Plaque growth is a chronic inflammatory response induced by the interactions between vascular endothelial cells, lipids, monocytes/macrophages, vascular smooth muscle cells and platelets in the arteries. The mechanism involves interactions between the activities of cellular and acellular components in plaque microenvironment. Experimental studies have revealed the contributing roles of many different biological factors and processes, such as:lipid depositioninflammationangiogenesishaemorrhage.Due to the difficulties in experimental measurement and visualisation of the multiscale process, and the complex nature of the local environment, these complex …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

Develop point-of-care microfluidic technologies for cardiovascular and cerebrovascular diseases

Excessive clotting (thrombosis) leads to the cardiovascular diseases such as heart attack and stroke, killing one Australian every 12 minutes. It has long been recognized that platelets play a central role in thrombosis and are unique in their ability to form stable adhesive interactions under conditions of rapid blood flow.We've recently discovered a new ‘biomechanical’ prothrombotic mechanism that highlights the remarkable platelet sensitivity to the shear stress gradients of blood flow disturbance. Importantly, we've found that current anti-thrombotic drugs, such …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

Investigating DNA repair mechanisms in aging adult stem cells

When we age the DNA repair systems of our cells become down regulated. This results in reduced DNA repair capacity, enhanced rates of mutation load and may lead to the development of chronic aging-associated diseases including osteoporosis, Alzheimer's and cancer(1). So it is no surprise that genome instability and stem cell exhaustion, which also strongly correlates with the accumulation of DNA damage, are considered hallmarks of aging(2). However, we still lack a clear understanding on how the decrease in DNA …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

Comparing the operationalisation and practice of engagement across different practice contexts

Engagement is a key concept in contemporary public relations theory and practice. Much of the current literature focuses on the operationalisation of engagement in a specific organisation or group of organisations within a single practice context. However, there are multiple practice contexts, and little research has been carried out to identify similarities and differences between the operationalisation of engagement across these areas.This study will compare and contrast the conduct of engagement across practice contexts, and analyse the significance of any …

Study level
PhD, Master of Philosophy
Faculty
QUT Business School
Lead unit
School of Advertising, Marketing and Public Relations

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