Student topics

Optimising the application rates of organic amendments in agricultural soils is one of the most promising and practical solutions to reduce nitrogen (N) losses into the environment while maintaining an economically-adequate crop production.Organic amendments alone often don't meet the crop's needs. Consequently, a supplementary application of N synthetic fertiliser is needed in conventional farming systems to meet perceived production needs.Accounting for the amount of plant-available N (PAN) released by organic amendments and combining this with N-fertiliser will:ensure N demands of …

Study level

PhD, Master of Philosophy, Honours

Faculty

Faculty of Science

School

School of Biology and Environmental Science

Research centre(s)

Centre for Agriculture and the Bioeconomy

This PhD project will be affiliated with FrontierSI and Value Australia and contribute to its goals and objectives around smart cities, digital twins, and automated land valuations. Although consumers contribute much of the data upon which these smart city technologies operate, its systems often remain opaque black boxes closed off to public understanding, scrutiny and control. There are also serious concerns around privacy and loss of autonomy.This PhD project addresses these issues by exploring new methods for the participatory visualisation …

Study level

PhD

Faculty

Faculty of Creative Industries, Education and Social Justice

School

School of Design

Research centre(s)

Design Lab

Programming robots to carry out desired tasks is difficult and time-consuming. This PhD project focuses on collaborative and instructional dialogue agents to help human operators program robot tasks.In this collaborative scenario, a human operator converses with an AI agent to explain the steps that are to be performed, using high-level references and abstractions that make sense to the human, as opposed to simple verbal instructions corresponding to rudimentary robot movements. The AI agent must interpret the high-level instructions and translate …

Study level

PhD

School

School of Design

Research centre(s)

Design Lab

Lung cancers are the leading cause of cancer related deaths in Australia, with a 5-year survival of 15%. With the emerging success of immune checkpoint blockage leading to durable responses and prolonged survival in 15-40% of cases, there is now a need for predictive biomarkers to guide selection for immunotherapies.The immune contexture of the tumour microenvironment (TME) is an important factor in dictating how well a tumour may respond to immune checkpoint therapies (1). Spatial and immunological composition with cellular …

Study level

PhD, Master of Philosophy

Faculty

Faculty of Health

School

School of Biomedical Sciences

When we age the DNA repair systems of our cells become down regulated. This results in reduced DNA repair capacity, enhanced rates of mutation load and may lead to the development of chronic aging-associated diseases including osteoporosis, Alzheimer's and cancer(1). So it is no surprise that genome instability and stem cell exhaustion, which also strongly correlates with the accumulation of DNA damage, are considered hallmarks of aging(2).However, we still lack a clear understanding on how the decrease in DNA repair …

Study level

PhD, Master of Philosophy, Honours

Faculty

Faculty of Health

School

School of Biomedical Sciences

Melanoma is the 4th most common cancer in Australia. The link between skin cancer and UV exposure is now well established. If a DNA damage induced by UV exposure is left unrepaired, the mutation generated in the genome can lead to cell death or cancer. It is thus highly important to understand of how a cell can repair DNA damage. The main pathway to repair UV DNA damaged is the nucleotide excision repair pathway (NER) (Kamileri I. et al, Trends …

Study level

Honours

Faculty

Faculty of Health

School

School of Biomedical Sciences

Transforming growth factor β (TGFβ) and its family members is involved in many phases of liver disease development and iron regulation. We have identified unexplored players in liver disease and iron-related disorders: TGF signalling intermediates. In this project, we build on our exciting findings to examine the molecular mechanisms involved in TGF signalling intermediates-mediated disease progression and their potential as targets for liver and iron-related disease.AimsThis project aims to:examine the expression of TGF signalling intermediates in the liverspecifically deplete TGF …

Study level

PhD, Master of Philosophy, Honours

Faculty

Faculty of Health

School

School of Biomedical Sciences

Iron is an element essential for virtually all life forms; aberrant iron metabolism is linked to many diseases. These include cancers, neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, iron overload and iron deficiency disorders, iron-loading anaemias, and the anaemia associated with chronic disease. Central to proper iron regulation is the appropriate expression and activity of the liver-expressed regulatory peptide, hepcidin, and the iron exporter, ferroportin (FPN). Modulating the expression and activity of hepcidin and FPN, and their interaction is …

Study level

PhD, Master of Philosophy, Honours

Faculty

Faculty of Health

School

School of Biomedical Sciences

Several studies have demonstrated the appropriateness of 3D organoid cultures over the conventional 2D cultures, the advantages of 3D models include replicating the complex attributes of the liver beyond liver-specific metabolism, such as increased cell density, organization, and cell–cell signalling, O2 zonation.In this project we will establish a novel in vitro 3D model to study hepatocyte biology in the context of liver disease. A more comprehensive approach to investigating the intercellular mechanisms of NAFLD will include co-culture of organoids with …

Study level

PhD, Master of Philosophy, Honours

Faculty

Faculty of Health

School

School of Biomedical Sciences

Epithelial Cells (ECs) constitute the border between the host immune system and an environment teeming with inhaled antigens. Work from us and others has highlighted that ECs have the ability to express the antigen processing and presentation machinery, Major Histocompatibility Complex class II (MHC II) that is important in initiating immune responses. MHC II expression and function on mucosal epithelial cells, is not well understood.Whilst MHC II is expressed by ECs, and is altered with inflammation, there is a paucity …

Study level

Master of Philosophy, Honours

Faculty

Faculty of Health

School

School of Biomedical Sciences

This research project acts upon recommendations from the Inquiry into the Quality of Care and Residential Aged Care in Australia IQCRAC (2018) by developing an inter-generational model for senior living within school campuses in consultation with industry partners. The project differs from existing programs by establishing an economic policy-driven 'shared campus facilities and services' approach which is person-centred, health focused and socially inclusive. The model intends to be translatable across diverse Australian contexts, from urban realms where land is limited, …

Study level

PhD, Master of Philosophy, Honours

Faculty

Faculty of Creative Industries, Education and Social Justice

School

School of Design

Research centre(s)

Design Lab

The health outcomes from traumatic brain injuries (TBIs) and concussion depend on the nature of the injury, but response also varies greatly between individuals, suggesting that genetic factors may play a role. In particular, due to effects of head trauma on balances of ions, neurotransmitters and energy use in the brain, there is suggestion that variation in the genes that encode proteins involved in these pathways, e.g. ion channels, may affect the risk of, as well as response to a …

Study level

PhD, Master of Philosophy, Honours

Faculty

Faculty of Health

School

School of Biomedical Sciences