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Impact of organoid culture on molecular characteristics and immune cell signal of bladder cancer (BIOM03)

Project code:BIOM03Project aims and objectives:Liver disease is a significant burden on society, affecting many in the prime of their life. Disordered iron metabolism is associated with many disorders and diseases including cancers, neurodegenerative and iron overload disorders, and anaemia associated with chronic disease.These two inter-related research themes are the focus of research in the Hepatogenomics Research Group in the School of Biomedical Sciences and IHBI; we hope to advance our understanding of these disorders at a molecular level with the …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

Impact of organoid culture on molecular characteristics and immune cell signal of bladder cancer (BIOM04)

Project code:BIOM04Area of research:CancerProject aims and objectives:Bladder cancer (BlCa) is the 9th most common cancer in Queensland, with an estimated 53% five-year survival rate in Australians. Treatment options for superficial, locally advanced and metastatic BlCa include platinum-based chemotherapy and intravesical immunotherapy in the form of a bacillus Calmette-Guérin (BCG) vaccine - a weakened, live bacterium that stimulates the immune response. As a result of developed resistance or progressive growth, BlCa tumour recurrence is a common clinical outcome. Thus, there is …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

Using a natural β-carboline dimer compound to target metabolic vulnerabilities linked to glycolysis in prostate cancer

Project code:BIOM08Area of research:CancerProject aims and objectives:Our research is focussed on understanding the mechanisms that lead to therapy failure in prostate cancer and how these can be targeted to prevent cancer deaths. One way prostate cancers become resistant is by reprogramming their metabolism to overcome metabolic stress induced by treatment. We aim to identify drugs that can target metabolic networks that are unique to cancer cells.Previous work in our lab has identified a compound, BD, isolated from a sea squirt …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

Testing of novel antibiotic-loaded nanoparticles for treatment of Chlamydia infection

C. trachomatis, sexually transmitted infections of both the female and male human reproductive tract, affects approximately 127 million people globally each year. The major concerning sequela of C. trachomatis infection is infertility in both men and women. This occurs by damaging the upper reproductive tracts, the ovaries and testes most importantly.The majority of research has been focussed on female disease, and male disease has been underestimated and understudied, particularly therapeutics for male infections. Antibiotic therapy is the only therapy currently …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

Dileneating immune response similarities between autoimmunity and chronic graft-versus-host disease

Project code:QIMR04Area of Research:CancerProject aims and objectives:Chronic graft-versus-host disease (GVHD) occurs in approximately 60-80% of long-term survivors of allogeneic stem cell transplantation (allo-SCT). This immunological complication is a major cause of morbidity and accounts for approximately one-quarter of the deaths in long-term transplant survivors. Clinical manifestations of chronic GVHD such as dry eyes, dry mouth and connective tissue disease closely resemble those of autoimmune disorders such as Sjogren's syndrome. Focal lymphocytic infiltrates of exocrine tissues (eg salivary glands), a characteristic …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

Mathematical modelling of the mechanobiology during plaque growth

Plaque growth is a chronic inflammatory response induced by the interactions between vascular endothelial cells, lipids, monocytes/macrophages, vascular smooth muscle cells and platelets in the arteries. The mechanism involves interactions between the activities of cellular and acellular components in plaque microenvironment. Experimental studies have revealed the contributing roles of many different biological factors and processes, such as:lipid depositioninflammationangiogenesishaemorrhage.Due to the difficulties in experimental measurement and visualisation of the multiscale process, and the complex nature of the local environment, these complex …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

Numerical study and parameter estimation for fractional order epidemic models

In the last decades, some epidemic diseases have been found to cause problems whose magnitude has increased dramatically. The World Health Organization (WHO) recently stated that it is the most important arthropod-borne viral disease of humans.These epidemic diseases include:dengueHIV/AIDSH1N1leptospirosismeaslesSIRSIRCSEIRsalmonella bacterial.Fractional derivatives epidemic systems have also been used to deal with some epidemic behaviors.This proposal aims to carry out innovative and novel research on developing effficient, robust and accurate computational models and parameter estimation techniques for fractional order epidemic models. …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mathematical Sciences

Fractional dynamic models for viscoelastic non-Newtonian fluid

This project aims to develop a mathematical framework to investigate the memory effect and anomalous diffusion in viscoelastic, non-Newtonian fluids.We aim to generate new knowledge on the formulation and estimation of the multi-term fractional space-time models governing the flow and heat transfer of these fluids. This will be based on recent advances in fractional calculus, computational methods and statistical techniques.We expect to uncover a new and efficient computational system to model the thermal properties as well as new insights into …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Mathematical Sciences

Computational modelling of liquid marbles

Liquid marbles are liquid droplets coated with super-hydrophobic particles. They possess interesting properties such as the ability to contain liquid content without wetting surfaces and enhanced elasticity.Numerous experimental studies on liquid marbles and their properties have already been reported in the literature. For example, novel microfluidic applications, miniature bioreactors and gas sensing mechanisms. Despite plenty of experimental work, there is limited computational modelling investigations of liquid marbles represented in literature.A successful numerical model would be able to derive new insights …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

Novel numerical methods and techniques for complex fractional dynamical systems and applications

In recent years, fractional models have attracted considerable interest because of their ability to model many phenomena. Anomalous diffusion phenomena are widely spread in nature and engineering.This proposal aims to carry out innovative and novel research on developing effficient, robust and accurate computational models for complex fractional dynamical systems.This project involves:fractional dynamical systemsnumerical methodsfinite differencefinite elementfinite volumemeshlessspectral methods and applications. …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Mathematical Sciences

Sustainable hydrogen production

The hydrogen economy is rapidly developing, especially in Japan and Australia.An attractive means of generating hydrogen is by splitting water using electrocatalysts.This project is focused on integration of concentrated solar photovoltaic systems with novel electrocatalysis systems with high efficiency for hydrogen production.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

An airway chip for screening viral infection mediated immune responses

Respiratory infections such as influenza, SARS-COV-2, COVID-19, and MERS are increasingly prevalent. Complications and related deaths arising from these infections are often the result of a “cytokine storm”, whereby there is an over production of proinflammatory soluble factors by immune cells, which dictates symptoms severity and mortality risk. Recent works showed that immunomodulatory therapy, with or without antiviral agents, may improve recovery outcome. However, the screening of suitable immune-modulatory and antiviral agents relies heavily on animal models which can't capture …

Study level
PhD, Master of Philosophy
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

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