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Retaining and regaining hydrogel mechanical properties

Hydrogels have great potential in tissue engineering and regenerative medicine, where they serve as an artificial extracellular matrix. However, they typically have poor mechanical properties, which limits their applications.  Double network hydrogels can overcome some of these limitations, with substantially improved stiffness and toughness compared to traditional single network hydrogels.  Nonetheless, double network hydrogels can lose these properties over time and with repeated loading.

Study level
Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Understanding and exploiting the phenomenal properties of collagen

Collagen is the most abundant protein in the human body and, as one of its principal building blocks, plays a dominant role in the function of many tissues. As such, the structure-property-function relationships in collagen are central to understanding health and disease, and developing materials-based strategies for regenerative medicine. A better understanding of these relationships further provides a biomimetic target for high-performance, multifunctional fibre-based materials in applications outside of biomedicine. The defining feature of collagen is an elegant structural motif …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Development of 3D tumour models for radiobiological research

Approximately 40 percent of cancer patients will receive radiation therapy as part of the management of their disease. Radiation can be used alone or in combination with other treatment modalities such as surgery, chemotherapy, and increasingly immunotherapy.Optimising the delivery of radiation, to take advantage of new treatment planning and delivery techniques, or to test new combinations of treatment modalities in a pre-clinical setting, has traditionally been performed using single layer 2D cell cultures and small animal models.Recently, it has become …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Time resolved EPID based thickness measurements for radiotherapy treatment verification

Verifying the delivery of radiation during radiotherapy treatments is increasingly important. The patient position and delivered radiation dose are equally important for a successful clinical outcome. Electronic Portal Imaging Devices (EPIDs) can be used to measure the radiation dose exiting the patient. We have developed a method for converting the measured signal in the EPID to tissue equivalent thickness, a surrogate for radiation dose. This project will investigate the real time measurement of the patient thickness during radiation delivery. …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Use of depth sensing technology in radiotherapy and medical imaging

Consumer-grade depth sensing technology has in recent years become widely available. A number of vendors have developed similar technologies.Some examples of these technologies include:Microsoft Kinect™ (now discontinued)Intel’s RealSense™Asus Xtion depth sensorQualcomm Spectra ISP platform, now in its second generation.The systems make use of camera technology that measures the distance to a surface. Rapid image acquisition can then enable real time motion detection of location of the surface. The infra-red transmitter and sensor use a time-of-flight method to construct a depth …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Patient-specific modelling of atherosclerosis

Rupture of atherosclerotic plaques without warning is responsible for most acute cardiovascular syndromes such as heart attack and stroke, and many victims who are apparently healthy die suddenly without prior symptoms. Such deaths could be prevented by surgery or alternative medical therapy if vulnerable plaques were identified earlier in their natural history. New diagnostic screening methods are urgently needed to assess plaque vulnerability to avoid such acute events.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Carpal forces and the role of ligaments as a tensile constraint

The hand is an important but complex anatomical structure. With the carpus being made from seven articulating bones stabilized by numerous ligaments. Damage to these structures can lead to impaired function and progression into severe arthritis.This projects aims to understand the role and loads that are undertaken by these important structures and in doing so realize the essential information for better ligament repair.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Constrained deep learning for medical image analysis

A new, exciting research project needs 2 postdoctoral fellowships and 3 PhD students to work on developing the next generation of neuroimaging diagnosis using MRI.This large $4.8M project involves:Australia’s premier research organisation, the CSIROQueensland University of TechnologyMaxwell+, a start-up developing AI for precision medicineI-MED, a large private radiology practice.The scholars based at QUT in Brisbane will develop new deep learning technologies for the analysis of brain MRI with the goal of predicting neurodegenerative diseases such as Alzheimer’s.This PhD project will …

Study level
PhD
Faculty
Science and Engineering Faculty
Lead unit
School of Electrical Engineering and Computer Science

One coating to rule them all: preventing infections to medical devices

Infections to medical devices are still a major complication. This project investigates a new antimicrobial coating that could be readily applied on all surfaces to prevent bacterial attachment and growth. The project is in collaborations with leading device R&D companies and manufacturers both in Australia and overseas and thus would give students opportunities for industry exposure.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Develop and implement a non-contact real-time respiratory monitoring technique, using low cost 3D camera technology, and explore its use in abdominal-thoracic cancer sites

Consumer-grade depth sensing technology has in recent years become widely available. A number of vendors have developed similar technologies, for example, Microsoft KinectTM (now discontinued), Intel’s RealSenseTM, the Asus Xtion depth sensor, and the Qualcomm Spectra ISP platform, now in its second generation.The systems make use of camera technology that measures the distance to a surface, rapid image acquisition can then enable real time motion detection of location of the surface. The infra-red transmitter and sensor use a time-of-flight method …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

A biofabricated surgical referral suite to predict intracranial aneurysm rupture

Intracranial aneurysms are bulging, weak areas of an artery that supply blood to the brain which are relatively common. While most aneurysms do not show symptoms, 1% spontaneously rupture which can be fatal or it can leave the survivor with permanent disabilities. This catastrophic outcome has motivated surgeons to operate on approximately 30% of aneurysms despite their rate of complications arising and cost of operation.The impact of aneurysm morphology on blood flow shear stress and rupture could educate surgical decision-making …

Study level
Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Chemistry, Physics and Mechanical Engineering

Hydrophobic and anti-fogging coatings for better endoscopic imaging

Keyhole surgeries rely on the use of so-called endoscopes that are essentially camera-guided instruments. Surgeons heavily rely on the visual feedback provided by such endoscopes in performing minimally invasive surgeries. However, the image quality provided by such endoscopes is routinely compromised when body fluids and fogging occlude the lens.In this project you will explore the use of novel nanomaterial in the role of hydrophobic and anti-fogging layer towards preventing the vision loss after repeated submersions in synthetic blood and similar …

Study level
PhD, Master of Philosophy, Honours
Faculty
Science and Engineering Faculty
Lead unit
School of Electrical Engineering and Computer Science

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