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Found 94 matching student topics

Displaying 1–12 of 94 results

Voluntary assisted dying, medical practitioners and conscientious objection

Should legislation permitting Voluntary Assisted Dying (VAD) provide medical practitioners with a right to conscientiously object to VAD and, if so, what should the scope of that right be?Should it include a right not to give a person asking about VAD any information about it? In Victoria the legislation provides an unrestricted right to conscientiously object whereas in Western Australia the right to object is qualified by a requirement to give the patient information about VAD. Which position is most …

Study level
PhD
Faculty
974868
School
School of Law
Research centre(s)

769301

Involuntary Treatment for Mental Illness: Under what circumstances is it ethically justified?

Dr Sam Boyle is looking for candidates wanting to explore the ethical and legal issues associated with providing involuntary treatment for people with mental illnesses. Candidates may explore this issue in relation to ethics, human rights, or any other relevant angle, including an international comparative approach.

Study level
PhD, Master of Philosophy, Honours
Faculty
974868
School
School of Law
Research centre(s)

769301

Advanced artificial intelligence based ultrasound imaging applications

Our research in the space of advanced quantitative medical imaging is investigating how to use ultrasound as a real time volumetric mapping tool of human tissues, to guide in a reliable and accurate way complex medical procedures1. We have developed several novel methods which make use of the most cutting-edge artificial intelligence technology2. For example, to show where the treatment target and the organs at risk are at all times during treatments in radiation therapy3, 4; or to inform robots …

Study level
PhD, Master of Philosophy
Faculty
974877
School
School of Clinical Sciences
Research centre(s)
Centre for Biomedical Technologies

Medical litigation, medical law and compensation for medical negligence

Tina Cockburn is interested in supervising PhD students in the area of patient safety law — focusing on medical litigation and compensation for medical negligence, communication of information to patients (including consent and post treatment open disclosure), regulation of health care professionals and the regulation of innovative medical treatment and new technologies.

Study level
PhD
Faculty
974868
School
School of Law
Research centre(s)

769301

Comprehensive strain-level characterisation of microbial communities associated with Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder driven by complex interactions between environmental, microbial and immune-mediated factors1,2. An unfavourable shift in gut microbiome composition, known as dysbiosis, is now considered a key feature of IBD 2-5, however it is unclear how specific microorganisms and their interactions with host cells contribute to disease onset and progression. Previous IBD studies have been largely limited to older sequencing methods with low phylogenetic and functional resolution. Furthermore, these studies have predominantly …

Study level
Master of Philosophy, Honours
Faculty
974877
School
School of Biomedical Sciences
Research centre(s)

Medical selfies and patient generated health data

Smartphones and wearable technologies provide exciting opportunities for patients and health professionals to transform healthcare.Patients can benefit from photos (“medical selfies”) taken on their smartphone to record a condition that they want to discuss with a health professional. Wearable devices allow patients to semi-automatically collect data about their physical activity, sleep, mood, diet, etc.This data can help patients to better understand a health concern, its underlying causes and the impact of treatments.Clinicians, on the other hand, can benefit from medical …

Study level
PhD, Master of Philosophy, Honours
Faculty
974872
School
School of Computer Science
Research centre(s)

Development of bioengineered 3D tumour models for preclinical breast cancer research

3D organoid model technologies have led to the development of innovative tools for precision medicine in cancer treatment. Yet, the lack of resemblance to native tumours, and the limited ability to test drugs in a high-throughput mode, has limited translation to practice.This project will progress organoid models by using advanced tissue engineering technologies and high-throughput 3D bioprinting to recreate ‘mini-tumours-in-a-dish’ from a patient’s own tumour cells, and study the effects of various components of the tumour microenvironment on drug response.In …

Study level
PhD, Master of Philosophy, Honours
Faculty
974877
School
School of Biomedical Sciences
Research centre(s)
Centre for Biomedical Technologies

Providing legal evidence for non-accidental scald burn injury

Although most burn injuries are completely accidental in nature, they can also occur due to neglect or abuse. Burn clinicians are often required to ascertain if the patient history and the wound are consistent with accidental or non-accidental injury. If the case goes to court, the clinician will prepare a medico-legal report as evidence. We have previously conducted studies examining the depth of burn injury after different durations and temperatures of hot water. This data can be used to predict …

Study level
Master of Philosophy, Honours
Faculty
974877
School
School of Biomedical Sciences
Research centre(s)

Identification and functional characterisation of genetic modifiers of iron overload

Iron is an element essential for virtually all life forms; aberrant iron metabolism is linked to many diseases. These include cancers, neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, iron overload and iron deficiency disorders, iron-loading anaemias, and the anaemia associated with chronic disease. Central to proper iron regulation is the appropriate expression and activity of the liver-expressed regulatory peptide, hepcidin, and the iron exporter, ferroportin (FPN). Modulating the expression and activity of hepcidin and FPN, and their interaction is …

Study level
PhD, Master of Philosophy, Honours
Faculty
974877
School
School of Biomedical Sciences
Research centre(s)

Developing in vitro 3D models to understand liver disease

Several studies have demonstrated the appropriateness of 3D organoid cultures over the conventional 2D cultures, the advantages of 3D models include replicating the complex attributes of the liver beyond liver-specific metabolism, such as increased cell density, organization, and cell–cell signalling, O2 zonation.In this project we will establish a novel in vitro 3D model to study hepatocyte biology in the context of liver disease. A more comprehensive approach to investigating the intercellular mechanisms of NAFLD will include co-culture of organoids with …

Study level
PhD, Master of Philosophy, Honours
Faculty
974877
School
School of Biomedical Sciences
Research centre(s)

Understanding the role of TGF signalling intermediates in liver and iron-related disease

Transforming growth factor β (TGFβ) and its family members is involved in many phases of liver disease development and iron regulation. We have identified unexplored players in liver disease and iron-related disorders: TGF signalling intermediates. In this project, we build on our exciting findings to examine the molecular mechanisms involved in TGF signalling intermediates-mediated disease progression and their potential as targets for liver and iron-related disease.Aim 1: To examine the expression of TGF signalling intermediates in the liver.Aim 2: To …

Study level
PhD, Master of Philosophy, Honours
Faculty
974877
School
School of Biomedical Sciences
Research centre(s)

Role of Peroxisomes in fatty liver disease

Liver disease is an increasing burden on society, accounting for more than 2 million deaths worldwide. Peroxisomes are multifunctional cellular organelles which are highly enriched in the liver. Our preliminary data shows that defects in a peroxisomal protein affects the ability of the liver to respond to toxic insults. In this research proposal, we build on these important and exciting findings to examine the relationship between peroxisome dysfunction and liver disease.Aim 1: To examine the expression and function of peroxisomal …

Study level
PhD, Master of Philosophy, Honours
Faculty
974877
School
School of Biomedical Sciences
Research centre(s)

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