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Visualisation of CRISPR targets

CRISPR-Cas9 technology allows us to modify virtually any gene in any organism of interest. It has generated a lot of interest, both in the research community and the general population.One of the crucial components of CRISPR experiments is the design of the 'guide RNAs' that will control where modifications occur.We have developed a software pipeline, named Crackling, to identify safe and effective guide RNAs across entire genomes. We're now seeking to develop a visualisation to communicate the results produced by …

Study level
Honours, Vacation research experience scheme
Faculty
Faculty of Science
School
School of Computer Science
Research centre(s)
Centre for Data Science

High-performance bioinformatic analysis of gene editing targets using Python Standard Libraries

The CRISPR-Cas9 technology allows the modification of virtually any gene in any organism of interest. It has generated a lot of interest, both in the research community and the general population.One of the crucial components of CRISPR experiments is the design of the 'guide RNAs' that will control where modifications occur. It is vital that the modification is made efficiently and at the desired location. This calls for bioinformatic approaches to design these guide RNAs.Our existing Python-based bioinformatic pipeline is …

Study level
Vacation research experience scheme
Faculty
Faculty of Science
School
School of Computer Science
Research centre(s)
Centre for Data Science

Investigating metal metabolism using cell and molecular biology techniques

Metals such as iron and copper are essential for life. Low or high amounts in the body can be damaging and hence levels are tightly regulated through various molecular pathways. Defects in these pathways can lead to genetic disorders such as haemochromatosis (iron overload), Wilson's disease (copper overload) or anaemia (iron deficiency).Increased understanding of the pathways regulating iron or copper homeostasis will be useful for the development of diagnostics and therapeutics for treating these disorders. This project will use cell …

Study level
Vacation research experience scheme
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

Investigating genetic variants involved in Wilson disease and copper metabolism using genome editing

Wilson disease (WD) is a genetic disorder of copper metabolism. It can present with hepatic and neurological symptoms, due to copper accumulation in the liver and brain (1). WD is caused by compound heterozygosity or homozygosity for mutations in the copper transporting P-type ATPase gene ATP7B. Over 700 ATP7B genetic variants have been associated with WD. Estimates for WD population prevalence vary with 1 in 30,000 generally quoted. Early diagnosis and treatment are important for successful management of the disease. …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Genomics and Personalised Health

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