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Early diagnosis of pregnancy complications using exosomes

Complications of pregnancy, including preterm birth represent the major causes of fetal and neonatal morbidity and mortality and potentially affect childhood and adult susceptibility to both cardiac and metabolic diseases. Early detection of these disorders is, therefore, essential to improve health outcomes for mother and baby.Exosomes are small (40-120 nm), stable, lipid bilayer nanovesicles identified in biological fluids (e.g. in milk, blood, urine and saliva). They contain a diverse array of signalling molecules, including mRNA, microRNA (miR), proteins, lipids and …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

Characterisation of grass pollen allergen extracts for diagnosis and therapy of patients with allergic rhinitis and asthma

Grass pollen allergens are the major outdoor allergen trigger for allergic asthma and rhinitis (hayfever) that affect up to 20% of Australians as well as 500 million people globally. Our research shows that patients with grass pollen allergy from subtropical regions show sensitisation and specific IgE and T cell recognition of allergens from subtropical grass pollens. Whilst allergen specific immunotherapy vaccine treatments are effective at reducing symptoms of hayfever and reduce progression to asthma, some skin prick test and allergen …

Study level
Master of Philosophy, Honours
Faculty
Faculty of Health
Lead unit
School of Biomedical Sciences

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