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Topological control over cell behaviour for robust additive tissue biomanufacturing

Hospital departments are adopting medical imaging, modelling, and 3D printing to automate personalised implant manufacture and avoid malpractice related to surgical handcrafting. Although several 3D printed implants are approved for medical use, their therapeutic value remains limited as acellular devices with coarse resolution. The ability to print scaffold implants with cell microenvironment precision has been achieved using melt electrowriting (MEW), an emerging technique frequently applied to produce cell culture scaffolds.In contemporary MEW studies, the effect of materials or pore sizes …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

A biofabrication surgical referral suite to predict intracranial aneurysm rupture

Intracranial aneurysms are bulging, weak areas of an artery that supply blood to the brain which are relatively common. While most aneurysms do not show symptoms, 1% spontaneously rupture which can be fatal or leave the survivor with permanent disabilities. This catastrophic outcome has motivated surgeons to operate on approximately 30% of aneurysms despite their rate of complications arising and cost of operation.The impact of aneurysm morphology on blood flow shear stress and rupture could educate surgical decision-making and better …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

3D-printed soft robotics to simulate popliteal artery endovascular treatment

Peripheral artery disease (PAD) is one of the most frequent cardiovascular diseases, affecting over 200 million people at an annual cost of $21 billion.PAD cases are predominately (80%) located within the popliteal artery, a highly flexible vessel behind the knee joint which twists, extends, and bends during standing, walking, and sitting.As a result, active or sedentary lifestyles play an important role in altering the biomechanics leading to popliteal diseases.Furthermore, surgical treatments within the popliteal artery have been inconsistent, with a …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
Lead unit
School of Mechanical, Medical and Process Engineering

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