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3D-printed soft robotics to simulate popliteal artery endovascular treatment

Peripheral artery disease (PAD) is one of the most frequent cardiovascular diseases, affecting over 200 million people at an annual cost of $21 billion.PAD cases are predominately (80%) located within the popliteal artery, a highly flexible vessel behind the knee joint which twists, extends, and bends during standing, walking, and sitting.As a result, active or sedentary lifestyles play an important role in altering the biomechanics leading to popliteal diseases.Furthermore, surgical treatments within the popliteal artery have been inconsistent, with a …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Topological control over cell behaviour for robust additive tissue biomanufacturing

Hospital departments are adopting medical imaging, modelling, and 3D printing to automate personalised implant manufacture and avoid malpractice related to surgical handcrafting. Although several 3D printed implants are approved for medical use, their therapeutic value remains limited as acellular devices with coarse resolution. The ability to print scaffold implants with cell microenvironment precision has been achieved using melt electrowriting (MEW), an emerging technique frequently applied to produce cell culture scaffolds.In contemporary MEW studies, the effect of materials or pore sizes …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

A biofabrication surgical referral suite to predict intracranial aneurysm rupture

Intracranial aneurysms are bulging, weak areas of an artery that supply blood to the brain which are relatively common. While most aneurysms do not show symptoms, 1% spontaneously rupture which can be fatal or leave the survivor with permanent disabilities. This catastrophic outcome has motivated surgeons to operate on approximately 30% of aneurysms despite their rate of complications arising and cost of operation.The impact of aneurysm morphology on blood flow shear stress and rupture could educate surgical decision-making and better …

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Development of bioengineered 3D tumour models for preclinical breast cancer research

3D organoid model technologies have led to the development of innovative tools for precision medicine in cancer treatment. Yet, the lack of resemblance to native tumours, and the limited ability to test drugs in a high-throughput mode, has limited translation to practice.This project will progress organoid models by using advanced tissue engineering technologies and high-throughput 3D bioprinting to recreate ‘mini-tumours-in-a-dish’ from a patient’s own tumour cells, and study the effects of various components of the tumour microenvironment on drug response.In …

Study level
PhD, Master of Philosophy, Honours
Faculty
Faculty of Health
School
School of Biomedical Sciences
Research centre(s)
Centre for Biomedical Technologies

3D-printed cellular structures for bone biomimetic implants

Bone implants have been increasingly used to repair and replace the host bones. One promising approach is creating three-dimensional (3D) porous cellular structures that provide suitable microenvironments to achieve the required integration and support under loading conditions.Both porosity and pore size have a direct influence on their functionalities for biomedical applications. Besides the intrinsic material properties of the polymers, the internal architecture of a cellular structure has a significant effect on its mechanical and biological behaviour.Improved specific mechanical properties have …

Study level
PhD, Master of Philosophy
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Materials Science
Centre for Clean Energy Technologies and Practices

Bio-inspired design to create strong and toughness composites

A fundamental challenge when designing materials for mechanical use is to attain both strength and toughness in one body. Conventional metallic materials generally have relatively large plasticity due to having a massive population of microstructural defects and effective plastic deformation mechanism. This has been exploited for fabricating tolerant (toughness) materials for structural applications. However, these structural defects render the materials relatively low strength and a low load-bearing capability. In contrast, ceramics and intermetallic compounds have higher strengths, owing to their …

Study level
PhD, Master of Philosophy, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)

Improving mechanical properties of hydrogels for tissue engineering

Hydrogels provide a hydrated, extracellular, matrix-like environment that allow for the culturing and study of cells. However, hydrogels are typically soft and fragile, which limits their potential for load-bearing applications such as cartilage tissue engineering.This project aims to improve the mechanical properties of hydrogels for tissue engineering using a range of experimental and theoretical approaches.

Study level
PhD, Master of Philosophy, Honours, Vacation research experience scheme
Faculty
Science and Engineering Faculty
School
School of Mechanical, Medical and Process Engineering
Research centre(s)
Centre for Biomedical Technologies

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