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Understanding and exploiting the phenomenal properties of collagen

Study level

PhD

Master of Philosophy

Honours

Vacation research experience scheme

Faculty/Lead unit

Topic status

We're looking for students to study this topic.

Supervisors

Professor Cameron Brown
Position
Professor of Biomedical Engineering & Director, MERF
Division / Faculty
Science and Engineering Faculty

External supervisors

  • Professor Andrew Carr, University of Oxford
  • Associate Professor Eamonn Gaffney, University of Oxford

Overview

Collagen is the most abundant protein in the human body and, as one of its principal building blocks, plays a dominant role in the function of many tissues. As such, the structure-property-function relationships in collagen are central to understanding health and disease, and developing materials-based strategies for regenerative medicine.

A better understanding of these relationships further provides a biomimetic target for high-performance, multifunctional fibre-based materials in applications outside of biomedicine. The defining feature of collagen is an elegant structural motif in which three parallel polypeptide strands coil with a one-residue stagger to form a right-handed triple helix, known as tropocollagen.

Tropocollagen is unstable at body temperature,driving its formation into supertwisted, right-handed microfibrils with molecules packed in a quasi-hexagonal lattice. This leads to a spiral-like structure within the mature collagen fibril, with interdigitated microfibrils forming a networked, nanoscale rope. The complex hierarchical structure within a collagen fibril provides interesting mechanical and electrical properties, and the basis for interactions with other tissue components. This allows collagen to modulate tissue structure and therefore function.

Through organisation and interactions on the nanometre to micrometre scales, collagen can work effectively in a wide variety of tissue configurations to provide exceptional mechanical performance, tuned to specialised applications.

Research activities

A range of projects are available to explore and exploit the interesting structure-property relationships in collagen. Specific projects are in network mechanics, biomaterial development, piezoelectricity and energy harvesting, diagnostics, regenerative medicine and the physics of disease. Many of these projects involve collaborations with the Botnar Research Centre and Mathematical Institute at the University of Oxford.

Outcomes

Potential outcomes from this work are wide-ranging, and will of course depend on the specific project. The student should discuss expected outcomes with Professor Brown.

Skills and experience

Students with a physics, materials, mechanical or electrical engineering background are encouraged to apply.

Scholarships

You may be able to apply for a research scholarship in our annual scholarship round.

Annual scholarship round

Keywords

Contact

Contact the supervisor for more information.