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How is mechanical guidance steering bone regeneration?

Study level

PhD

Master of Philosophy

Honours

Vacation research experience scheme

Faculty/Lead unit

Science and Engineering Faculty

School of Mathematical Sciences

Topic status

We're looking for students to study this topic.

Supervisors

Dr Pascal Buenzli
Position
Lecturer
Division / Faculty
Science and Engineering Faculty

External supervisors

  • Thomas L Andersen, University of Southern Denmark

Overview

A critical step in tissue regeneration is the guidance of cells to the areas needing repair. In bone tissues, regeneration is achieved by synchronised groups of bone-resorbing and bone-forming cells that need to reach damaged areas deep in bone tissue. These cells are also required to inflict minimal collateral damage to the mechanical integrity of bone tissue. To achieve this, the cells are steered by signals from a dynamic network of cells that incorporates signals from damaged areas and local mechanical clues.

Research activities

You will develop mathematical and computer models of mechanically-guided cell migration during bone tissue regeneration to simulate the resorptive tracks of bone-resorbing cells and compare them with experimental data.

Depending on the scope and interest, this project may consider:

  • how the shape of resorption cavities depend on mechanical cell steering
  • spatial relationships between resorptive tracks and bone microstructure
  • the guidance provided by the dynamic network of cells.

Outcomes

An understanding of general principles of the guidance of regenerative cells in bone, with particular relevance to age-related or disease-related bone loss.

Skills and experience

To be considered for this project, we expect you to have some proficiency in differential equations and computer modelling.

Keywords

Contact

Contact the supervisor for more information.