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How do collisions control tissue growth?

Study level

PhD

Master of Philosophy

Honours

Vacation research experience scheme

Faculty/Lead unit

Science and Engineering Faculty

School of Mathematical Sciences

Topic status

We're looking for students to study this topic.

Supervisors

Dr Pascal Buenzli
Position
Lecturer
Division / Faculty
Science and Engineering Faculty

Overview

Biological tissue growth occurs mostly at or near the tissue's surface, where spatial interactions between the tissue and its surroundings can have strong influences onto the local rate of growth.

This project will investigate how collisions between molecules or cells with an evolving tissue are dependent on the tissue shape and how these collisions may control tissue growth rate and tissue composition.

Research activities

This project will derive general equations for the co-evolution of impact density and interface movement. You will investigate conditions leading to quasi-steady states (travelling waves) and simulate these equations numerically.

The model will be applied to relevant situations such as bone remodelling, wound closure, scratch assays or bioscaffold tissue growth to understand the specific influence of interface geometry.

Outcomes

Results from the mathematical models will be compared with experimental data available through collaboration or from literature as well as previous mathematical models of bioscaffold tissue growth.

Skills and experience

We expect you to have some proficiency in differential equations and computer modelling.

Scholarships

You may be able to apply for a research scholarship in our annual scholarship round.

Annual scholarship round

Keywords

Contact

Contact the supervisor for more information.