There is still much to learn about the biomechanics of the arthritic knee joint. In particular, improving our understanding of the osteochondral interface may prove to be a critical step in better understanding aetiology and treatment of the diseased joint.
We believe combining the complementary approaches of experimental cell-biology and computational modelling will lead to a breakthrough.
- develop a finite element model (FEM) of the interface between bone and cartilage (osteochondral interface) in a knee joint
- use an existing database of micro-scale imaging (micro-CT) to develop the FEM geometry
- draw on both literature-based and experimental data to develop benchmark properties describing the mechanical behaviour of the model constituents
- use single axis loading conditions to simulate the joint mechanics in the standing knee
- conduct image analysis of micro-CT data
- develop and analyse finite element models.
The model will be applied to establish whether:
- mechanical information describing the osteochondral interface can be gained from FEM
- we can use such a model to better understand the region-specific biomechanics of arthritic cartilage in a degenerate joint.
Skills and experience
Undergraduate-level FEM experience is required for this student topic.
As a preferred application, you'll:
- be studying a mechanical or medical engineering major
- have prior experience with image processing.
Contact the supervisor Dr Paige Little for more information.