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Design of Free Radical Dynamic Nuclear Polarisation (DNP) Agents

Study level

PhD

Master of Philosophy

Honours

Vacation research experience scheme

Faculty/Lead unit

Topic status

We're looking for students to study this topic.

Supervisors

Dr James Blinco
Position
Senior Lecturer
Division / Faculty
Science and Engineering Faculty

Overview

Nuclear magnetic resonance (NMR) is one of the most widely used analytical and structural elucidation techniques in chemistry and materials science.

It is also the underlying principle of magnetic resonance imaging (MRI), an important clinical imaging modality.

However it is a relatively insensitive technique compared to other spectroscopic methods.

This project will look to investigate the synthesis of stable, free-radical compounds with application as magnetic resonance enhancement agents.

Research activities

Some of the activities that you will be doing include:

  • synthesis of small molecule organic compounds
  • characterisation using spectroscopic and physical techniques.

Outcomes

We aim to synthesise a series of novel, radical-containing molecules.

Pending on the success of the synthesis, you will also be able to undertake preliminary studies to assess the ability for these molecules to be used as imaging agents.

Skills and experience

This project will be suited for you if you are undertaking the chemistry major as this project will involve organic synthesis.

An interest in biological/medical chemistry is desirable.

Keywords

Contact

Contact the supervisor for more information.