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Creation of fibre meshworks at moving interfaces

Study level

Master of Philosophy

Honours

Vacation research experience scheme

Faculty/Lead unit

Science and Engineering Faculty

School of Mathematical Sciences

Topic status

We're looking for students to study this topic.

Supervisors

Dr Pascal Buenzli
Position
Lecturer
Division / Faculty
Science and Engineering Faculty

Overview

Extracellular matrix (ECM) secreted by cells is composed of a meshwork of fibres infiltrated with proteins and/or minerals. This fibre meshwork often matures after its creation by rearranging its structure, e.g. according to local mechanical clues, or by the infiltration of new molecules [1]. In this project, the fibre meshwork will be represented by a continuous tensorial field [2].

References

  1. Bidan C et al. Gradual conversion of cellular stress patterns into pre-stressed matrix architecture during in vitro tissue growth, J R Soc Interface 13:20160136
  2. Cumming BF, McElwain DLS, Upton Z (2010) A mathematical model of wound healing and subsequent scarring, J R Soc Interface 7:19-34

Research activities

You will derive evolution equations to describe fibre creation at moving cell membranes and the subsequent maturation of the meshwork.

Outcomes

Applications include the investigation of twisted fiber arrangements in tissues grown in bioscaffold constructs [1], the generation of an anistropic network of interconnected cells in bone, and anisotropic molecular transport in the meshwork.

Scholarships

You may be able to apply for a research scholarship in our annual scholarship round.

Annual scholarship round

Keywords

Contact

Contact the supervisor for more information.