Pathogenic bacteria have a range of mechanisms by which they perceive their environment. It is not clear if pathogenic bacteria have the capacity to perceive the tissue type in which they reside but, if such capacity is present, it is likely to involve the action of secreted proteases.
While working on this project you will:
- develop methods to produce and isolate peptide mixtures from a range of tissue types
- determine the dose-response of the peptide mixtures on the transcriptome of P. aeruginosa.
The aim of the project is to determine if constitutive secretion of proteases is a mechanism by which pathogenic bacteria 'perceive' their environment.
Skills and experience
You will well regarded for this project if you have knowledge and strong practical skills in the following scientific fields:
- medical microbiology
- molecular genetics
- protein chemistry
You may be able to apply for a research scholarship in our annual scholarship round.
Contact Mark Harrison for more information.