Everything you need to know as a first-time student.
Information and support for postgraduate study.
Courses, supervisors and your life as a researcher.
Step-by-step application guides for our courses.
Get financial support for your studies. Find a scholarship that's right for you.
Options like part-time, external and online study can help you tailor how you learn.
Boost your career or extend your skills with a short course.
Discover our campuses, courses and entry requirements.
Email: firstname.lastname@example.org Phone: +61 7 3138 2000 Mon-Fri, 8.30am-5pm
Our internationally recognised research is supported by state-of-the-art research infrastructure.
Considering research with us? Here's what to expect.
We value and promote integrity and ethical responsibility in all research we conduct.
PhDs, research masters and professional doctorates.
Apply for scholarships to cover your tuition fees and living expenses.
Our researchers work in supportive and established networks.
We offer quality-assured research solutions for industry, government and non-profit sectors.
Our strengths and areas of focus in research.
Browse our experts or find a supervisor.
We collaborate with industry partners to research solutions for real-world problems, and to give our students hands-on experience in the workplace.
Work with our students and graduates, sponsor scholarships, prizes or events, or become an industry partner.
We offer commercial research and consultancy services, research commercialisation, and workplace training and development.
We offer short courses to help you advance your career and expand your skills.
We're working with a range of industry partners and collaborators.
Boeing Australia have collaborated on projects with us and provided sponsorship, and their staff have taught in our avionics program.
We are a highly successful and globally positioned Australian university with an applied emphasis in courses and research.
Make a real impact by giving to QUT and supporting our students, researchers and community.
Our history, key statistics, sustainability initiatives and programs and Indigenous acknowledgement.
Meet our staff and executive team.
Our awards, accreditation details, research rankings and scholarly achievements.
Our plans for expanding our university's achievements in learning, teaching and research.
Policies, procedures and annual reports.
What's on at QUT.
Want to work with us? See available jobs.
Email: email@example.com Phone: +61 7 3138 2000 Mon-Fri, 8.30am-5pm.
Find out more about our commitment to the AHRC's anti-racism initiative.
Our graduates run successful businesses, conduct ground-breaking research and make significant contributions to their communities.
We celebrate our alumni with annual awards for graduates and students.
Get involved with QUT by engaging with and supporting our current students.
Once you've graduated, we encourage you to keep in touch with the QUT community and your fellow alumni.
Email: firstname.lastname@example.org Phone: +61 7 3138 4778 Mon-Fri, 8.30am-5pm
Greg Creed won the 2014 QUT Alumnus of the Year Award for his achievements in business.
Step-by-step guide to applying as an international student.
We offer scholarships for international students to help with study and living costs.
You may be able to meet with a QUT staff member or official representative in your city.
Find out more about living and studying in Brisbane.
While you're studying here, you can access a range of support services to help you adjust to life in Brisbane.
Come to QUT for one or two semesters.
Online: Enquiry form for international students
Freecall: 1800 181 848 (within Australia)
Phone: +61 3 9627 4853 (outside Australia)
Email: email@example.com Phone: +61 7 3138 2361
World-class education and research facilities sit alongside lifestyle, sporting and creative hubs at our campuses.
Our four libraries offer diverse collections, study spaces and free public services.
Our researchers work at specialised facilities in Brisbane and across Queensland.
Our cultural, entertainment and function venues are open to the public.
Hire one of our unique spaces for your next event.
Our Science and Engineering Centre is a place for students, researchers, academics and the public to learn and collaborate.
You are here:
We're looking for students to study this topic.
Hypothesis: Mutations in the kinase domain that provide resistance to Ponatinib are distinct from those that provide resistance to Dovitinib and may show that Ponatinib is more effective as a first line therapy.
Our laboratory identified mutations in FGFR2 in endometrial cancer (EC) (Pollock et al 2007) and has showed that inhibition of FGFRs induces cell death. Kinase inhibitors have been associated with remarkable clinical responses, however patients often develop resistance mutations in the kinase domain, which prevents drug binding and the cancer returns.
Our lab generated preclinical data that patients with mutations affecting the N550 codon, occurring in 25%, of EC patients will show intrinsic resistance to Dovitinib but should be more sensitive to Ponatinib. Within a large collaboration, our lab is initialling a clinical trial to test the efficacy of the multi-kinase inhibitor Ponatinib (Ariad), in EC patients. The aim of this project is to perform a functional BaF3 mutation screen to identify mutations in FGFR2 that provide acquired resistance to commercially available Ponatinib. These mutations will then be mapped on to the existing crystal structures of the FGFR2 kinase domain to determine the molecular mechanism underlying them, which will assist in the design of second line therapies.
Institute of Health and Biomedical Innovation
Institute of Health and Biomedical Innovation
Please contact the supervisors.