Dr Mark Woolf
This person does not currently hold a position at QUT.
BiographyResearch theme: Health
Research discipline: Medical Sciences
The surface of the cornea abuts directly up against the surrounding conjunctiva. It is not clear how the boundary between these two distinctly different tissues is maintained. This is an important question since common diseases affecting the eye often destroy the cornea-conjunctiva barrier. In such cases, the conjunctiva spreads across the surface of the eye, thus impairing vision. The present hypothesis is that cells derived from the surface of the cornea and conjunctiva respectively will display evidence of boundary-forming function in vitro, and that this property is related to production of molecules which belong to the Eph/ephrin family of proteins.
Current projects focus on examining the behaviour of corneal epithelial cells and conjunctival epithelial cells when cultured together in vitro, studying the expression of Eph and ephrin family proteins across the cornea-conjunctiva boundary in situ, and investigating the respective in vitro responses of corneal epithelial and conjunctival epithelial cells to select Eph and ephrin proteins identified in Aim 2 as potential markers of tissue boundary.
Areas of expertise
- Visual Psychophysics
- Vision and Driving
Clinical Sciences, Other Biological Sciences
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008
- PhD (Queensland University of Technology)
Professional memberships and associations
- Member of The Australian Institute of Biology
- Associate Fellow of The Australasian College of Road Safety
- IHBI Early Career Scheme, 2008. What prevents the conjunctiva from spreading across the surface of the cornea? – Is there a role for Eph/ephrin protein interactions?
Selected research projects
- Physiology and Driver Monotony
- Effect of Age and Visual Impairment on Traffic Sign Detection