Dr Adam Polkinghorne
This person does not currently hold a position at QUT.
BiographyResearch theme: Health
Research discipline: Cell and Molecular Biosciences
- Development of a vaccine for management and control of chlamydial infections in koalas: Chlamydial infection and disease are contributing to a significant decline in the wild koala population in mainland Australia. In collaboration with Australia Zoo and other partners, we are in the process of developing and testing a vaccine, which could be used to prevent the spread of this disease.
- Molecular evolution of Chlamydia pecorum infections in animals, including the koala: Chlamydia pecorum is a bacterial pathogen of sheep and cattle. Our group has previously shown that C.pecorum infections in koalas may have originated from sheep and cattle brought to Australia. With the recent advent of genome sequencing, we plan to investigate the evolution of this bacterial species in Australia.
- Molecular characterisation of Chlamydia-related epitheliocystis agents in wild and cultured fish species: Epitheliocystis is a skink and gill disease of wild and cultured fish species and has long been suspected to be caused by Chlamydia-like organisms. Advances in molecular diagnostics have recently confirmed this link and we are interested in using molecular methods to identify and characterise causative agents of this disease.
Veterinary Sciences, Microbiology, Biochemistry and Cell Biology
Field of Research code, Australian and New Zealand Standard Research Classification (ANZSRC), 2008
- PhD (Queensland University of Technology)
- Nufer L, Schifferli A, Zimmermann D, Segner H, Steiner P, Vaughan L, Schmidt-Posthaus H, Polkinghorne A, (2012) A natural freshwater origin for two chlamydial species, Candidatus Piscichlamydia salmonis and Candidatus Clavochlamydia salmonicola, causing mixed infections in wild brown trout (Salmo trutta), Environmental Microbiology, 14 (8), pp. 2048-2057.
- Wan C, Loader J, Hanger J, Beagley K, Timms P, Polkinghorne A, (2011) Using quantitative polymerase chain reaction to correlate Chlamydia pecorum infectious load with ocular, urinary and reproductive tract disease in the koala (Phascolarctos cinereus), Australian Veterinary Journal, 89 (10), pp. 409-412.
- Marsh J, Kollipara A, Timms P, Polkinghorne A, (2011) Novel molecular markers of Chlamydia pecorum genetic diversity in the koala (Phascolarctos cinereus), BMC Microbiology, 11, pp. 1-15.
- Polkinghorne A, Schmidt-Posthaus H, Meijer A, Lehner A, Vaughan L, (2010) Novel Chlamydiales associated with epitheliocystis in a leopard shark triakis semifasciata, Diseases of Aquatic Organisms, 91 (1), pp. 75-81.
- Bertelli C, Collyn F, Croxatto A, Ruckert C, Polkinghorne A, Kebbi-Beghdadi C, Goesmann A, Vaughan L, Greub G, (2010) The waddlia genome: A window into chlamydial biology, PLoS One, 5 (5), pp. 1-10.
- Polkinghorne A, Borel N, Becker A, Lu Z, Zimmerman D, Brugnera E, Pospischil A, Vaughan L, (2009) Molecular evidence for chlamydial infections in the eyes of sheep, Veterinary Microbiology, 135 (1-2), pp. 142-146.
- Polkinghorne A, Ziegler U, Gonzalez-Hernandez Y, Pospischil A, Timms P, Vaughan L, (2008) Chlamydophila pneumoniae HflX belongs to an uncharacterized family of conserved GTPases and associates with the Escherichia coli 50S large ribosomal subunit, Microbiology, 154 (11), pp. 3537-3546.
- Polkinghorne A, Hogan R, Vaughan L, Summersgill J, Timms P, (2006) Differential Expression of Chlamydial Signal Transduction Genes in Normal and Interferon Gamma-induced Persistent Chlamydophila Pneumoniae Infections, Microbes and Infection, 8 (1), pp. 61-72.
- Devereaux L, Polkinghorne A, Meijer A, Timms P, (2003) Molecular Evidence for Novel Chlamydial Infections in the Koala (Phascolarctos Cinereus), Systematic and Applied Microbiology, 26, pp. 245-253.