Overview
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How to grow corneal and retinal tissue for transplantation using stem cells and novel biomaterials? Substantial progress has been made in the treatment of severe corneal disorders by using tissue transplants grown in the laboratory from a patient's own stem cells. Our team completed the first Australian clinical trial of this technique in 2001 and is currently investigating ways to improve clinical outcomes through incorporation of further cell types and a fibrous protein extracted from silk-worm silk known as fibroin. Similar strategies are also being explored for treatment of retinal diseases.
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How does a pterygium form and how can we stop it recurring? Pterygium is a common disorder related to UV-light exposure and is characterised by development of a triangular-shaped growth of abnormal tissue across the surface of the eye. These growths commonly become inflamed and eventually require surgical removal in order to maintain clear vision. Historically, pterygia display a high rate of recurrence, but our surgical colleagues have developed new approaches with significantly improved outcomes. By studying the structure of the tissue removed during surgery we hope to learn more about how a pterygium forms and why certain treatments work better than others.
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How does the cornea stay clear? Maintenance of a clear cornea is obviously essential for vision. Our aim is therefore to investigate the mechanisms that prevent the adjacent non-transparent sclera and conjunctiva tissue from encroaching upon the cornea. Our present hypothesis is based upon a role for molecular sign-posts distributed along the tissue boundary.
- Research leader
- Organisational unit
- Lead unit Faculty of Health Other units
- Research area
- Vision Improvement
Associate Professor Damien Harkin
