Overview
Bone Metastasis Research: Investigating the mechanism through which breast and prostate cancer cells differentially form osteolytic and osteoblastic lesions, respectively, in bone. Cancer cells are introduced into the tibia of immunosuppressed mice; histomorphometric analysis is undertaken to determine bone architectural and cellular changes.
Fracture Healing Research: Development of a novel, standardised murine fracture and fixation model to study the role of the mechanical environment on bone fracture healing. Femoral osteotomies are stabilised by rigid or flexible fixation plates; callus formation and tissue differentiation is evaluated using histological analysis and 3D computer remodelling.
- Research leader
- Organisational unit
- Lead unit Faculty of Health Other units
- Research area
- Cancer
Dr Laura Gregory
