Overview
Topic status: We're looking for students to study this topic.
Antioxidants produce cardioprotection by several mechanisms including direct scavenging of superoxide anion, as well as the reduction in the levels of C–reactive protein (CRP) and the membrane attack complex (MAC) and the expression of antioxidant enzymes. Furthermore, some drugs currently in clinical use, such as anti–hypertension reagents including angiotensin–converting enzyme inhibitors and angiotensin receptor blockers and anti–hyperlipidemic reagents like statins, may also protect the heart via antioxidant action in addition to their primary pharmacological effect.
This project involves the design, synthesis and pharmacological evaluation of dual acting antioxidant adenosine receptor agonists, whereby known antioxidant moieties will be incorporated in the design of new adenosine receptor agonists with the view to enhancing receptor affinity and selectivity in addition to providing antioxidant activity. Paralleling this approach, antioxidant moieties will be incorporated into structures of drugs such as Edaravone which are currently used to treat stroke and other ischemic events.
- Study level
- PhD
- Supervisors
- QUT
- Organisational unit
Science and Engineering Faculty
- Research area
- Contact
- Please contact the supervisor for enquiries.
Professor Steven Bottle
Dr Kathryn Fairfull-Smith
