Overview
Topic status: We're looking for students to study this topic.
Drug-loaded polymer micro/nanoparticles have been found to increase dispersion of drugs from powder formulations together with the prolongation of the therapeutic action and stabilization of the drugs. It is worthwhile to note that the application of drug-loaded polymers in DPIs has not been well studied. Therefore, the purpose of the present research work is to develop a novel controlled release dry powder inhalation system by the utilization of drug-loaded biodegradable polymer nanospheres for maximizing drug delivery for systemic disorders. This study involves the synthesis and characterization of precisely engineered biodegradable polymer particles (with defined surface functionality), which will undergo a phase inversion phenomenon to release a bound/embedded drug delivered via pulmonary route. The outcome of this project will be to enable the development of controlled release of drugs from DPI formulations to get prolonged therapeutic action. This study would therefore allow us to develop and optimize the effectiveness of the controlled release preparation and improve patient compliance. This work may be further extended to develop targeted delivery of drugs for the management of specific diseases.
- Study level
- PhD
- Supervisors
- QUT
- Organisational unit
Science and Engineering Faculty
- Research area
- Contact
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Please contact the supervisor.
Dr Nazrul Islam
