Overview
Topic status: We're looking for students to study this topic.
Aerosol delivery of drugs for asthma has evolved extensively in the last three decades. Dry powder inhaler (DPI) formulation is one of the most useful aerosol preparation in which drugs are formulated as carrier-based interactive mixtures with micronised drug particles (<5") adhered onto the surface of large inert carriers (lactose powders). The powder formulation is aerosolized through a device, where the drug particles are separated from the carrier or deagglomerates from the mixtures, and the dose is delivered into the deep lungs patient's inspiratory force. The introduction of micro/nanoparticles for aerosol delivery of drugs has become very popular, and micro/nanoparticles particles of biodegradable polymers have been demonstrated to deliver various drugs into the lungs with improved dispersion from the formulation. Pulmonary delivery of drugs with nanomaterials provides a non-invasive means to provide not only local lung effects, but also systemic bioavailability of various drugs. This project aims to investigate the dispersion of micro/nanaoparticle (1, 2) on the pulmonary delivery of various drugs for a wide range of local and systemic disorders using dry powder inhaler formulations.
This project could result in novel intellectual property. Furthermore, outcome of this research will be published in high impact journals which would increase the strength of our research activity to attract external funding (such ARC/ ARC linkage grants and Pharmaceutical Industry) for future research.
Methods and techniques that will be used/developed in the course of this project:
- Preparation of polymeric micro/nanoparticles
- Formulation of powdered drugs and in-vitro delivery studies using Twin-stage impinger (TSI); Analyse/Assay of drugs (UV and HPLC)
- Morphological characterization of particles by SEM, ESEM
- Determination of amorphous content by X-ray diffraction
- Study level
- PhD, Honours
- Supervisors
- QUT
- Organisational unit
Science and Engineering Faculty
- Research area
- Contact
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Please contact the supervisor.
Dr Nazrul Islam
Emeritus Professor Graeme George
Dr Tim Dargaville
