Overview
Topic status: We're looking for students to study this topic.
Neurodegenerative diseases are a major health issue that seriously affects quality of life and are a significant burden on health care systems around the world. The mechanism of action of many current therapies is unknown and consequently, there is a great need for highly-directed therapeutic strategies to aid in the understanding of the free radical basis underpinning neurodegeneration. This project will involve the synthesis and evaluation of new dual-acting antioxidants which combine nitroxides with dietary antioxidants. The development of the proposed novel nitroxides will aid in identifying the role that reactive oxygen species play in neurodegeneration for a variety of diseases. It will also facilitate the exploration of new chemical pathways and probe the tolerance of the nitroxide moiety to a range of different chemical reactions and biochemical transformations. Project supported by bursaries from the ARC Centre of Excellence in Free Radical Chemistry and Biotechnology.
- Study level
- Honours
- Supervisors
- QUT
- Organisational unit
Science and Engineering Faculty
- Research area
- Contact
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Please contact the supervisor.
Dr Kathryn Fairfull-Smith
