Overview
Topic status: We're looking for students to study this topic.
Haematopoietic stem cells (HSC) derived from umbilical cord blood are in many cases the preferred donor material in HSC transplants for patients suffering from haematological malignancies such as leukaemia. The clinical outcome of such HSC transplants is cell dose dependent, and thus there is significant motivation to try to increase the cell dose through the culture of these cells prior to transplant. An honours student will work with our team to develop bioreactor technologies and to investigate redox signalling phenomena that will enable the successful ex vivo expansion of HSCs for the purpose of enhancing the treatment options for patients suffering from haematological malignancies. A background in biology or biomedical engineering is desired.
Approaches
Tissue culture, PCR, microfabrication, flow cytometry.
References:
- Doran, M.R., et al., Membrane Bioreactors Enhance Microenvironmental Conditioning and Tissue Development. Tissue Eng Part C Methods, 2009.
- Study level
- Honours
- Supervisors
- QUT
- Organisational unit
Science and Engineering Faculty
- Research area
- Contact
- Contact supervisor for enquiries.
