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The overall aim of this project is to introduce novel and innovative biotechnology approaches to contribute new strategies to the prevention of cumulative musculoskeletal injury/disorder in occupations with high physical demands and high incidence of injury. Work–related musculoskeletal disorders are the most common condition for workers compensation claims representing 43% of all disease and injury claims. Globally musculoskeletal conditions are one of the leading causes of morbidity and disability with significant health care and personal costs. Therefore, the specific goal of this research is to apply advanced biotechnology strategies and techniques to identify and collect quantitative measures of candidate diagnostic and prognostic biomarker profiles of musculoskeletal injury that will ultimately be developed into cheap and non–invasive diagnostic and prognostic tools for use in labour intensive heavy industries such as mining and construction. This is a collaborative project between the Tissue Repair and Regeneration Program (Science and Engineering Faculty) and the Injury Prevention Domain (Faculty of Health).
Methods and techniques developed
This project will adopt cutting edge proteomic biomarker detection techniques such as:
- surface enhanced laser desorption/ionisation time of flight mass spectrometry (SELDI TOF MS)
- high pressure liquid chromatography (HPLC)
- liquid chromatography tandem mass spectrometry (LCMS/MS)
- 2D–gel electrophoresis including 2D–DIGE
- other more traditional protein biochemistry techniques.