Overview
Topic status: In progress
Overview
Our research team initially identified hSSB1 as a key DNA repair protein (Richard et al., Nature, 2008). hSSB1 is thought to function in the detection and repair of DNA double strand breaks and is essential for cellular viability. Although we know hSSB1 is ubiquitinated we do not know the mechnism of this post translational process or the biological consequence of mono-ubiquitination of hSSB1. This project will aim to map the ubiquitination sites, identify the ubiquitin ligase and determine in part the biological consequence of ubiquitination.
Research activities
This project will involve a large number of biological techniques to answer some specific questions. These include tissue culture, immuno-blotting, immunofluorescence and cell viability assays.
Expected outcomes
This project will significantly increase our understanding of the role of ubiquitination in controlling the cellular functions of hSSB1.
Duration of project
This is an 8 week project and the start date can be discussed
Number of hours
37 hours per week
- Study level
- Vacation research experience scholarship
- Supervisors
- QUT
- Organisational unit
Science and Engineering Faculty
- Research area
- Keywords
- hSSB1, DNA, biology
- Contact
- Please contact the supervisor for enquiries.
Dr Derek Richard
