Overview
Topic status: We're looking for students to study this topic.
Pain associated with cartilage damage and decay is the leading cause of pain and immobility in Australia. Our team has recently developed a novel method to differentiate mesenchymal stem cells into cartilage cells and a bioreactor system for the ex vivo production of cartilage tissue. We are looking to recruit an honours student to aid in the further development of this bioreactor system and the cell differentiation process.
A background in biology or biomedical engineering is desired.
Aim
The ultimate aim of the project is the production of functional cartilage tissue from patients' own bone marrow stem cells.
Approaches
The approaches undertaken include:
- tissue culture
- PCR
- micro-fabrication.
References
- Doran, M.R., et al., Membrane Bioreactors Enhance Microenvironmental Conditioning and Tissue Development. Tissue Eng Part C Methods, 2009.
- Markway, B.D., et al., Enhanced chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells in low oxygen environment micropellet cultures. Cell Transplant, 2010. 19(1): p. 29-42.
- Study level
- Honours
- Supervisors
- QUT
- Organisational unit
Science and Engineering Faculty
- Research area
- Keywords
- cartilage, tissue, cartilage tissue
- Contact
- Please contact the supervisor for enquiries.
Dr Michael Doran
